N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide | 96116-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide
• 英文别名: acetic acid-[4-(2-dimethylamino-ethoxy)-anilide]；Essigsaeure-[4-(2-dimethylamino-aethoxy)-anilid]；1-(2-Dimethylamino-aethoxy)-4-acetamino-benzol；N-[4-[2-(dimethylamino)ethoxy]phenyl]acetamide
• CAS: 96116-29-9
• 化学式: C₁₂H₁₈N₂O₂
• mdl: MFCD21369561
• 分子量: 222.287
• InChiKey: BYTDCDSUYXMVTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide 在 盐酸 、 potassium carbonate 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 47.0h， 生成 (Z)-octadec-9-en-1-yl 10-(4-(((4-(2-(trimethylammonio)ethoxy)phenyl)imino)methyl)phenoxy)decyl phosphate
  参考文献：
  名称：

  A sustainable self-reproducing liposome consisting of a synthetic phospholipid

  摘要：

  A novel phosphoric membrane lipid (phospholipid) bearing an oleyl group as one of the hydrophobic chains formed a liposome with a thin lamella in water. Since the anionic membrane of pre-existing liposomes acted as a catalytic surface in phosphate buffer, membrane lipids could be generated from their precursor in an autocatalytic manner without the inclusion of catalytic amphiphiles in the liposome. The morphological changes of this anionic liposome were monitored both by flow cytometry and optical microscopy, and it was found that the liposomes deformed into a budding shape, followed by division, after the addition of a membrane precursor. Hence, this anionic monocomponent liposome could be regarded as a sustainable self-reproducing system. This liposome was also able to provide a reaction cavity for enzymatic reactions, such as DNA amplification by a polymerase chain reaction.

  DOI：

  10.1016/j.chemphyslip.2019.04.007
• 作为产物：
  描述：

  N-[4-(羟基乙氧基)苯基]乙酰胺 在 氯化亚砜 作用下， 生成 N-(4-(2-(dimethylamino)ethoxy)phenyl)acetamide
  参考文献：
  名称：

  THE SYNTHESIS OF SOME ACETYLAMINO-PHENOXYETHYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01138a012

文献信息

• Calixarene-Mediated Liquid Membrane Transport of Choline Conjugates 2: Transport of Drug-Choline Conjugates and Neurotransmitters
  作者：Birendra Babu Adhikari、Sahar Roshandel、Ayu Fujii、Michael P. Schramm

  DOI：10.1002/ejoc.201403519

  日期：2015.4

  effect selective transport of distinct molecular payloads through a liquid membrane. The secret to this success lies in the attachment of a receptor-complementary handle. We find that the trimethylammonium ethylene group present in choline is a general handle for the transport of drug and drug-like species. Furthermore, neurotransmitters possessing ionizable amine termini are also transported. Some limitations

  下边缘羧酸杯[n]芳烃和上边缘膦酸官能化杯[4]芳烃影响不同分子有效负载通过液膜的选择性转运。成功的秘诀在于受体互补手柄的连接。我们发现胆碱中存在的三甲基铵乙烯基团是药物和类药物物种运输的一般处理方法。此外，还运输了具有可电离胺端的神经递质。随着有效载荷变得越来越亲脂，已经发现了该策略的一些局限性。这些进展揭示了在囊泡和细胞系统中合成受体介导的选择性小分子转运的新方法。
• A sustainable self-reproducing liposome consisting of a synthetic phospholipid
  作者：Muneyuki Matsuo、Shota Ohyama、Kotoba Sakurai、Taro Toyota、Kentaro Suzuki、Tadashi Sugawara

  DOI：10.1016/j.chemphyslip.2019.04.007

  日期：2019.8

  A novel phosphoric membrane lipid (phospholipid) bearing an oleyl group as one of the hydrophobic chains formed a liposome with a thin lamella in water. Since the anionic membrane of pre-existing liposomes acted as a catalytic surface in phosphate buffer, membrane lipids could be generated from their precursor in an autocatalytic manner without the inclusion of catalytic amphiphiles in the liposome. The morphological changes of this anionic liposome were monitored both by flow cytometry and optical microscopy, and it was found that the liposomes deformed into a budding shape, followed by division, after the addition of a membrane precursor. Hence, this anionic monocomponent liposome could be regarded as a sustainable self-reproducing system. This liposome was also able to provide a reaction cavity for enzymatic reactions, such as DNA amplification by a polymerase chain reaction.
• THE SYNTHESIS OF SOME ACETYLAMINO-PHENOXYETHYLAMINES¹
  作者：ROBERT M. HERBST、JOHN V. SIMONIAN

  DOI：10.1021/jo01138a012

  日期：1952.4