palmitic peroxyanhydride | 2697-96-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: palmitic peroxyanhydride
• 英文别名: hexadecanoyl peroxide；dipalmitoyl peroxide；Dipalmitoyl-peroxid；Di-hexadecanoyl-peroxid；Palmitinsaeure-peroxid；Dipalmitoyl Peroxid；Dihexadecanoyl peroxide；hexadecanoyl hexadecaneperoxoate
• CAS: 2697-96-3
• 化学式: C₃₂H₆₂O₄
• 分子量: 510.842
• InChiKey: QMXBAGNATMRETP-UHFFFAOYSA-N

物化性质

• 熔点：
  70.5-71.5 °C
• 沸点：
  564.9±33.0 °C(Predicted)
• 密度：
  0.906±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.9
• 重原子数：
  36
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  palmitic peroxyanhydride 、 甲萘醌 在 Petroleum ether 作用下， 生成 2-Pentadecyl-3-methyl-1,4-naphthoquinone
  参考文献：
  名称：

  Fieser; Oxford, Journal of the American Chemical Society, 1942, vol. 64, p. 2063

  摘要：

  DOI：
• 作为产物：
  描述：

  棕榈酰氯 在 sodium hydroxide 、 乙醚 、 双氧水 作用下， 生成 palmitic peroxyanhydride
  参考文献：
  名称：

  Fieser et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3177

  摘要：

  DOI：

文献信息

• Siosomal formulation for intracellular delivery and targeting of therapeutic agents
  申请人：Salama, Zoser B.

  公开号：EP2384743A1

  公开（公告）日：2011-11-09

  The invention relates to a carrier and targeting system for the intracellular delivery and triggered release of a siosome- and/or siosome-liposome-entrapped or encapsulated active substance or therapeutic agent. The invention further relates to the targeted release and delivery of doxorubicin, cis-platin, carbo-platin and/or oxali-platin, characterized in that one or more anionic lipids, such as cholesteryl hemisuccinate residues, cardiolipin and/or their derivatives and/or other anionic groups, are covalently linked to the silicone central atom of the silanes, sugar silanes and/or amino-sugar silanes. The invention further relates to the use of cationic lipids that are covalently attached to the silicone central atom of the silanes. The invention also relates to a method for preparing such carrier and targeting systems and methods for their administration.

  该发明涉及一种用于细胞内递送和触发释放siosome和/或siosome-脂质体包埋或封装活性物质或治疗剂的载体和靶向系统。该发明还涉及对阿霉素、顺铂、卡铂和/或奥沙利铂的靶向释放和递送，其特征在于将一个或多个阴离子脂质，如胆固醇半琥珀酸酯残基、心磷脂和/或它们的衍生物和/或其他阴离子基团，共价连接到硅烷、糖硅烷和/或氨基糖硅烷的硅中心原子上。该发明还涉及将阳离子脂质共价连接到硅烷的中心原子的使用。该发明还涉及一种制备这种载体和靶向系统的方法以及它们的给药方法。
• Radical Decarboxylation/Annulation of Acrylamides with Aliphatic Acyl Peroxides
  作者：Changduo Pan、Yu Fu、Qingting Ni、Jin-Tao Yu

  DOI：10.1021/acs.joc.7b00663

  日期：2017.5.5

  A radical decarboxylation/annulation of acrylamides with aliphatic acyl peroxides was developed, giving a series of linear alkylated oxindoles in moderate to good yields. The reaction used aliphatic acyl peroxides as the linear alkyl radical source and tolerated a broad scope of substrates under metal-free conditions, offering a simple and efficient approach toward alkylated oxindoles.

  开发了使用脂肪族酰基过氧化物进行丙烯酰胺的自由基脱羧/环化反应，以中等至良好的收率得到了一系列线性烷基化的吲哚。该反应使用脂肪族酰基过氧化物作为线性烷基自由基源，在无金属条件下可耐受多种底物，为烷基化的吲哚提供了一种简单有效的方法。
• 一种3-甲基-3-烷基吲哚酮衍生物的合成方法
  申请人：江苏理工学院

  公开号：CN107151224A

  公开（公告）日：2017-09-12

  本发明公开了一种3‑甲基‑3‑烷基吲哚酮衍生物的合成方法，包括下列步骤：在通氮气情况下，含苯基的有机溶剂中，以N‑芳基丙烯酰胺(Ⅰ)为原料，以过氧化正烷基酰(II)为烷基化试剂，在80‑120℃的反应温度下，反应12‑24小时，即得3‑甲基‑3‑烷基吲哚酮衍生物(Ⅲ)。本发明操作简单，合成方法简单以及本发明产物的产率较高，无需要过渡金属催化，无自由基重排副产物，后处理简单，具有较强的实用价值。
• Synthetic analogs having the activity of naturally occurring forms of
  申请人：——

  公开号：US03974187A1

  公开（公告）日：1976-08-10

  Synthetic 2,3-dimethoxy-5-methyl-1,4-benzoquinone is converted into a series of new 6-alkyl derivatives. These 6-alkyl derivatives have straight carbon chains which are both saturated and unsaturated. The unsaturated derivatives contain one, two, three and four double bonds. These new synthetic quinones are analogs of the naturally occurring forms of coenzyme Q and have the same fundamental electron-transfer capacity of the natural forms of coenzyme Q. Although the degree of the activity of these new synthetic analogs differ, some of these new synthetic analogs are effective substitutes for the natural forms of coenzyme Q.

  合成的2,3-二甲氧基-5-甲基-1,4-苯醌被转化为一系列新的6-烷基衍生物。这些6-烷基衍生物具有直链碳链，既有饱和的，也有不饱和的。不饱和的衍生物包含一、二、三和四个双键。这些新的合成喹诺醌是辅酶Q天然形式的类似物，具有与天然辅酶Q相同的基本电子转移能力。尽管这些新的合成类似物的活性程度不同，但其中一些新的合成类似物是天然辅酶Q的有效替代品。
• Contrast agents
  申请人：——

  公开号：US20040146462A1

  公开（公告）日：2004-07-29

  Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations comprise an injectable aqueous medium comprising dispersed gas and an injectable oil-in-water emulsion in which the oil phase comprises a diffusible component capable of diffusion in vivo into the dispersed gas to promote temporary growth thereof, such that material present at the surfaces of the dispersed gas phase and material present at the surfaces of the dispersed oil phase have affinity for each other, e.g. as a result of having opposite charges. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences between return signal intensity from normal and hypoperfused myocardial tissue respectively.

  使用新型含气对比剂制剂进行超声成像，特别是心肌和其他组织的灌注成像，这些制剂促进体内气相的可控、暂时性生长，因此可以作为沉积的灌注示踪剂。这些制剂包括可注射的水性介质，其中包含分散的气体和可注射的油水乳液，其中油相包含可扩散的成分，能够在体内扩散到分散的气体中促进其暂时性生长，使分散气体相和分散油相表面的物质互相吸引，例如由于具有相反的电荷。在心脏灌注成像中，这些制剂可以优势地与血管扩张药物（如腺苷）同时使用，以增强正常和低灌注心肌组织的回波信号强度差异。