BS2G Crosslinker | 215597-83-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: BS2G Crosslinker
• 英文别名: 1-[5-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-5-oxopentanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid
• CAS: 215597-83-4
• 化学式: C₁₃H₁₄N₂O₁₄S₂
• 分子量: 486.4
• InChiKey: OWSWOWLMQKUWTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  253
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• [EN] SILICON PARTICLES TARGETING TUMOR CELLS<br/>[FR] PARTICULES DE SILICIUM CIBLANT LES CELLULES TUMORALES
  申请人：UNIV ROVIRA I VIRGILI

  公开号：WO2015177340A1

  公开（公告）日：2015-11-26

  A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound,is useful in the treatment of cancer by producing cell death after particle internalization.

  一种硅颗粒，包括硅体、包围硅体的功能化二氧化硅表面，以及特异性靶向肿瘤细胞的靶向基团，以及可选的酶代谢化合物，在颗粒内部化后通过诱导细胞死亡，在癌症治疗中具有用处。
• Silicon particles targeting tumor cells
  申请人：Universitat Rovira I Virgili

  公开号：EP2946793A1

  公开（公告）日：2015-11-25

  A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound, is useful in the treatment of cancer by producing cell death after particle internalization.

  硅粒子由硅体、围绕硅体的功能化二氧化硅表面、特异性靶向肿瘤细胞的靶向分子以及可选择的酶代谢化合物组成，可在粒子内化后导致细胞死亡，从而用于治疗癌症。
• PROCESS FOR PRODUCING LOW-CONCENTRATION GEL USING GEL-PRECURSOR CLUSTERS, AND GEL OBTAINED BY SAID PRODUCTION PROCESS
  申请人：The University of Tokyo

  公开号：EP3269755A1

  公开（公告）日：2018-01-17

  [Problem] To provide a gel which can be produced in a short time, has controlled properties such as modulus and expansion pressure, and has a low polymer concentration. [Solution] A process for producing a polymer gel in which gel-precursor clusters have been crosslinked with one another to form a three-dimensional network structure, characterized by comprising a) a step in which monomer or polymer units that are present in a concentration less than a critical gelation concentration are crosslinked to form the gel-precursor clusters, the gel-precursor clusters having a storage modulus G' and a loss modulus G" which satisfy the relationship G'

  [问题]提供一种可在短时间内生产、具有可控特性（如模量和膨胀压力）且聚合物浓度较低的凝胶。[解决方案] 一种生产聚合物凝胶的工艺，其中凝胶前体簇相互交联以形成三维网络结构，其特 征在于：a) 第一步，将浓度小于临界凝胶化浓度的单体或聚合物单元交联以形成凝胶前体簇、凝胶前体簇具有满足 G'交联剂使凝胶前体簇相互交联以获得具有三维网络结构的凝胶的步骤。
• GEL MATERIAL FOR OPHTHALMIC TREATMENT USE
  申请人：The University Of Tokyo

  公开号：EP3400972A1

  公开（公告）日：2018-11-14

  Provided is a gel material for ophthalmic treatment useful as a synthetic vitreous body which is a novel intraocular tamponade material having a low swelling pressure, an appropriate elastic force, and no toxicity to ocular tissues, specifically, to retinas, and which is capable of stably maintaining a long-term stable tamponade effect. A gel material for ophthalmic treatment including a hydrogel in which a gel precursor cluster crosslinks to form a three-dimensional network. The gel precursor cluster has a structure with crosslinked monomer units or crosslinked polymer units present at concentrations less than a critical gelation concentration, and the gel precursor cluster has a relationship of G' < G" where G' represents a storage elastic modulus and G" represents a loss elastic modulus. The hydrogel has a polymer content of 50 g/L or less, a storage elastic modulus G' of 1 to 10,000 Pa at a frequency of 1 Hz, and a fractal dimension of 1.5 to 2.5.

  本发明提供了一种用于眼科治疗的凝胶材料，可用作合成玻璃体，它是一种新型眼内填塞材料，具有较低的膨胀压力和适当的弹性力，对眼部组织，特别是视网膜无毒性，并能长期稳定地保持填塞效果。 一种用于眼科治疗的凝胶材料，包括一种水凝胶，其中凝胶前体团交联形成三维网络。凝胶前体簇具有交联单体单元或交联聚合物单元的结构，其存在浓度小于临界凝胶化浓度，凝胶前体簇具有 G' < G" 的关系，其中 G' 代表储存弹性模量，G" 代表损失弹性模量。水凝胶的聚合物含量为 50 克/升或更少，在频率为 1 赫兹时，储存弹性模量 G' 为 1 至 10,000 帕，分形维数为 1.5 至 2.5。
• Renal cell populations and uses thereof
  申请人：inRegen

  公开号：US10363274B2

  公开（公告）日：2019-07-30

  The present invention concerns enriched heterogeneous mammalian renal cell populations characterized by biomarkers, and methods of making and using the same.

  本发明涉及以生物标志物为特征的富集异质性哺乳动物肾细胞群，以及制造和使用这些细胞群的方法。