N-(4-nitro-benzenesulfonyl)-methionine | 99842-31-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(4-nitro-benzenesulfonyl)-methionine
• 英文别名: N-(4-Nitro-benzolsulfonyl)-methionin；4-Methylsulfanyl-2-[(4-nitrophenyl)sulfonylamino]butanoic acid
• CAS: 99842-31-6
• 化学式: C₁₁H₁₄N₂O₆S₂
• 分子量: 334.374
• InChiKey: FSMAKDQLPKEBNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  163
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  DL-蛋氨酸 、 对硝基苯磺酰氯 生成 N-(4-nitro-benzenesulfonyl)-methionine
  参考文献：
  名称：

  Wasserlösliche Sulfonamide. 1. Mitteilung: p-Nitrobenzolsulfenyl- und p-Nitrobenzolsulfonylglycinderivate

  摘要：

  DOI：

  10.1002/ardp.19562890507

文献信息

• KOMBINATION VON LIPONSÄURE UND C 1-DONOREN ZUR BEHANDLUNG VON STÖRUNGEN DES ZENTRALEN NERVENSYSTEMS
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1289521A2

  公开（公告）日：2003-03-12
• INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO
  申请人：Tract Pharmaceuticals, Inc.

  公开号：EP3638267A1

  公开（公告）日：2020-04-22
• [DE] KOMBINATION VON LIPONSÄURE UND C1-DONOREN ZUR BEHANDLUNG VON STÖRUNGEN DES ZENTRALEN NERVENSYSTEMS<br/>[EN] COMBINATION OF LIPOIC ACID AND C1 DONORS FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM<br/>[FR] COMBINAISON D'ACIDE LIPOIQUE ET DE DONNEURS D'UNITES C1 POUR LE TRAITEMENT DE TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：BASF AG

  公开号：WO2001085165A2

  公开（公告）日：2001-11-15

  Die vorliegende Erfindung betrifft die Verwendung von Liponsäure und C1-Donoren, insbesondere S-Adenosylmethionin und/oder 5-Methyltetrahydrofolat, zur Behandlung von Störungen des zentralen Nervensystems, Mittel mit einer entsprechenden Wirkstoffkombination sowie Mittel in Form von Handelspackungen mit entsprechenden Kombinationspräparaten oder Monopräparaten zur kombinierten Anwendung.
• [EN] METHODS AND COMPOSITIONS RELATING TO HIGH RESOLUTION STRUCTURE OF NON-SEGMENTED NEGATIVE STRAND VIRUS L PROTEINS<br/>[FR] PROCÉDÉS ET COMPOSITIONS SE RAPPORTANT À UNE STRUCTURE HAUTE RÉSOLUTION DE PROTÉINES L DE VIRUS À BRIN NÉGATIF NON SEGMENTÉ
  申请人：HARVARD COLLEGE

  公开号：WO2016094869A1

  公开（公告）日：2016-06-16

  Described herein are methods and compositions relating to the high resolution 3D structure determination for non-segmented negative strand (NNS) virus multifunction L proteins. High resolution 3D structure as described permits the application of a range of rational drug design and screening approaches to the identification of inhibitors of any of the varying functions of the NNS virus L proteins and thereby facilitates the identification of antiviral agents.
• [EN] INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO<br/>[FR] CELLULES SOUCHES ASSOCIÉES À LA MALADIE INFLAMMATOIRE DE L'INTESTIN, AGENTS CIBLANT LESDITES CELLULES SOUCHES ET UTILISATIONS ASSOCIÉES
  申请人：TRACT PHARMACEUTICALS INC

  公开号：WO2018204913A1

  公开（公告）日：2018-11-08

  The present invention addresses IBD from the standpoint of mucosal stem cells cloned from defined regions of the gastrointestinal tract. In the case of pediatric Crohn's disease, for example, isolation of those stem cells according to the methods of the present invention reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.