ethyl 4-(2-formylphenoxy)benzoate | 1173170-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-(2-formylphenoxy)benzoate
• CAS: 1173170-29-0
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: HJYAYTWJJQEZIO-UHFFFAOYSA-N

物化性质

• 沸点：
  390.1±27.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(2-formylphenoxy)benzoate 在 吡啶 、 chloropyridinecobaloxime(III) 作用下， 以 二氯甲烷 为溶剂， 以16 %的产率得到Ethyl 9-oxo-9H-xanthene-2-carboxylate
  参考文献：
  名称：

  Cobaloxime 直接激发醛激活 C(sp2)−H 键催化析氢芴酮合成

  摘要：

  已经成功开发了通过钴肟催化直接激发醛以激活其 C ( sp 2 )-H 键。在照射下，芳香醛中间体的高反应性光激发三重态被基态催化剂拦截，从而导致在没有任何外部氧化剂和氢作为副产品。

  DOI：

  10.1002/anie.202214944
• 作为产物：
  描述：

  过氧化氢酶 、 2-氟苯甲醛 在 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 3.0h， 以89%的产率得到ethyl 4-(2-formylphenoxy)benzoate
  参考文献：
  名称：

  铑催化的芳氧基C的裂解将2-芳氧基苯甲醛重排为2-羟基二苯甲酮。O键

  摘要：

  混洗中丢失：通过铑催化的芳氧基CO和醛CH键的同时裂解，标题化合物发生了前所未有的重排（请参阅方案）。该反应容许各种催化反应性取代基的存在，例如芳基卤化物，腈和酯。

  DOI：

  10.1002/anie.201103599

文献信息

• tert-Butoxide mediated cascade desulfonylation/arylation/hydrolysis of cyclic sulfonyimines using diaryliodonium salts: synthesis of diaryl ether derivatives bearing a 2-aldehyde group
  作者：Xiaofei Qian、Jianwei Han、Limin Wang

  DOI：10.1039/c6ra19313g

  日期：——

  Cascades of cyclic sulfonyimines mediated by tBuOK with diaryliodonium salts has been developed, giving the diaryl ethers in good yields. Furthermore, bulky ortho-substituted diaryl ethers with an aldehyde group can be obtained easily in comparision with metal-catalyzed protocols.

  已经开发了由t BuOK与二芳基碘鎓盐介导的级联环磺酰亚胺，可得到高收率的二芳基醚。此外，与金属催化的方案相比，可以容易地获得具有醛基的庞大的邻取代的二芳基醚。
• SUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：Abelman Matthew

  公开号：US20090181986A1

  公开（公告）日：2009-07-16

  The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Q1, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.

  本发明涉及新型杂环化合物及其在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。特别是，在某些实施例中，该化合物的结构由公式（I）给出：其中Q1、Q2、R2、R3、R4、R5和R6如本文所述。本发明还涉及制备该化合物的方法，以及包含这种化合物的制药组合物。
• Rhodium-Catalyzed Xanthone Formation from 2-Aryloxybenzaldehydes via Cross-Dehydrogenative Coupling (CDC)
  作者：Ping Wang、Honghua Rao、Ruimao Hua、Chao-Jun Li

  DOI：10.1021/ol203381q

  日期：2012.2.3

  A concise and straightforward strategy to construct a xanthone skeleton via an intramolecular cross-dehydrogenative coupling (CDC) of 2-aryloxybenzaldehydes has been developed. The reaction proceeded smoothly without any need of preactivation of the aldehyde group. It can tolerate various functional groups and provides an applicable protocol to construct a wide range of xanthone derivatives.
• [EN] OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS<br/>[FR] DÉRIVÉS DE DIHYDROPYRIDINE, DE DIHYDROPYRIMIDINE ET DE DIHYDROPYRANE FACULTATIVEMENT CONDENSÉS, JOUANT LE RÔLE DE BLOQUEURS TARDIFS DES CANAUX SODIQUES
  申请人：CV THERAPEUTICS INC

  公开号：WO2010002483A1

  公开（公告）日：2010-01-07

  The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein Ql, Q2, R2, R3, R4, R5, and R6 are as described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
• Rearrangement of 2-Aryloxybenzaldehydes to 2-Hydroxybenzophenones by Rhodium-Catalyzed Cleavage of Aryloxy CO Bonds
  作者：Honghua Rao、Chao-Jun Li

  DOI：10.1002/anie.201103599

  日期：2011.9.12

  Lost in the shuffle: An unprecedented rearrangement of the title compounds proceeds by the simultaneous rhodium‐catalyzed cleavage of aryloxy CO and aldehyde CH bonds (see scheme). The reaction tolerates the presence of various catalytically reactive substituents such as aryl halides, nitrile, and esters.

  混洗中丢失：通过铑催化的芳氧基CO和醛CH键的同时裂解，标题化合物发生了前所未有的重排（请参阅方案）。该反应容许各种催化反应性取代基的存在，例如芳基卤化物，腈和酯。