1-<2-ethylamino>anthraquinone | 156338-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-<2-ethylamino>anthraquinone
• 英文别名: 1-[2-[N,N-bis(2-aminoethyl)]aminoethylamino]anthraquinone；1-[2-[Bis(2-aminoethyl)amino]ethylamino]anthracene-9,10-dione
• CAS: 156338-97-5
• 化学式: C₂₀H₂₄N₄O₂
• 分子量: 352.436
• InChiKey: AOQOOBZLAGWDJR-UHFFFAOYSA-N

物化性质

• 沸点：
  581.2±50.0 °C(Predicted)
• 密度：
  1.278±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-<2-ethylamino>anthraquinone 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 生成
  参考文献：
  名称：

  Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher

  摘要：

  A set of 15mer linear oligoDNA probes bearing a modified nucleoside conjugated with a polyamine/fluorescein/anthraquinone reporting moiety were synthesized. In a single-stranded form, the fluorescence generated by the excitation of fluorescein was efficiently quenched, while marked recovery of the fluorescence was observed when the probes formed duplexes with the fully complementary strand. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.016
• 作为产物：
  描述：

  三(2-氨基乙基)胺 、 1-氯蒽醌 反应 2.0h， 以19%的产率得到1-<2-ethylamino>anthraquinone
  参考文献：
  名称：

  DNA Intercalators Bearing Metal Chelating Moiety. Ternary Complexes of Polyamine Containing Anthraquinone Derivative-DNA-Cu(II) and Its DNA Cleavage Activity

  摘要：

  与 Cu(II) 和 ds-DNA 连接的多胺 DNA 介导物形成了稳定的三元络合物，其中一些可诱导 ds-DNA 链的裂解。反应活性与配合物的立体化学特征有关。

  DOI：

  10.1246/cl.1994.1053

文献信息

• A Cyclic Sugar Unit Interacts More Strongly with DNA Than Do Open-Chain Polyol Counterparts in Sugar-Linked Synthetic DNA Intercalators
  作者：Atsushi Kumasaki、Tomoko Goto、Shigeo Nakamura、Toshihiro Ihara、Makoto Takagi

  DOI：10.1246/cl.2001.370

  日期：2001.4

  We synthesized new DNA intercalators, polyol- or cyclic sugar-linked anthraquinone derivatives. The binding affinity of these DNA intercalators is suggested to be controlled by the configuration and steric structure of sugar chain with the cyclic sugar chain interacting more strongly than the open-chain polyol unit with double stranded DNA.

  我们合成了新的 DNA 中间体--多元醇或环糖连接的蒽醌衍生物。这些 DNA 中间体的结合亲和力受糖链的构型和立体结构控制，环糖链比开链多元醇单元与双链 DNA 的相互作用更强。
• Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher
  作者：Sinichi Kodama、Satoko Asano、Tomohisa Moriguchi、Hiroaki Sawai、Kazuo Shinozuka

  DOI：10.1016/j.bmcl.2006.02.016

  日期：2006.5

  A set of 15mer linear oligoDNA probes bearing a modified nucleoside conjugated with a polyamine/fluorescein/anthraquinone reporting moiety were synthesized. In a single-stranded form, the fluorescence generated by the excitation of fluorescein was efficiently quenched, while marked recovery of the fluorescence was observed when the probes formed duplexes with the fully complementary strand. (C) 2006 Elsevier Ltd. All rights reserved.
• DNA Intercalators Bearing Metal Chelating Moiety. Ternary Complexes of Polyamine Containing Anthraquinone Derivative-DNA-Cu(II) and Its DNA Cleavage Activity
  作者：Toshihiro Ihara、Akiko Inenaga、Makoto Takagi

  DOI：10.1246/cl.1994.1053

  日期：1994.6

  Polyamine-linked DNA-intercalators formed stable ternary complexes with Cu(II) and ds-DNA, some of which induced the chain cleavage of ds-DNA. The reactivity was related to the stereochemical features of the complexes.

  与 Cu(II) 和 ds-DNA 连接的多胺 DNA 介导物形成了稳定的三元络合物，其中一些可诱导 ds-DNA 链的裂解。反应活性与配合物的立体化学特征有关。