N-phenyl-D-gluconamide | 24758-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-D-gluconamide
• 英文别名: D-gluconic acid anilide；D-Gluconsaeure-anilid；D-Gluconsaeure-anilid; (d-Glykonsaeure)-anilid；(d-Glykonsaeure)-anilid；D-Glucon-anilid；(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxy-N-phenylhexanamide
• CAS: 24758-64-3
• 化学式: C₁₂H₁₇NO₆
• 分子量: 271.27
• InChiKey: UKVPDYNUTQILLT-CHWFTXMASA-N

物化性质

• 沸点：
  706.8±60.0 °C(Predicted)
• 密度：
  1.527±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  130
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-phenyl-D-gluconamide 、 乙酸酐 在 吡啶 作用下， 反应 24.0h， 以95%的产率得到2,3,4,5,6-penta-O-acetyl-N-phenyl-D-gluconamide
  参考文献：
  名称：

  Optically active sugar thioamides from δ-gluconolactone

  摘要：

  This paper describes a facile and rapid approach to N-alkyl- and N-aryl-thiogluconamides employing delta-gluconolactone as starting material. The protocol involves a three-step sequence to afford the corresponding thioamides as crystalline substances in moderate to good yields. The Lawesson reagent was found to be the reagent of choice to accomplish the key transformation amide-thioamide. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00140-3
• 作为产物：
  描述：

  2,3,4,5,6-penta-O-acetyl-N-phenyl-D-gluconamide 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 N-phenyl-D-gluconamide
  参考文献：
  名称：

  Bognar,R. et al., Chemische Berichte, 1963, vol. 96, p. 689 - 693

  摘要：

  DOI：

文献信息

• Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
  申请人：K.U. LEUVEN RESEARCH & DEVELOPMENT

  公开号：EP0998946A1

  公开（公告）日：2000-05-10

  The invention relates to a non porphyrin compound or a pharmaceutically acceptable salt thereof, suitable for in vitro, in vivo and/or ex vivo use as a diagnosticum and/or pharmaceutical, said compound comprising: a targeting agent for targeting a specific area, such as an organ and/or tissue, a labelling agent L for labelling the targeted area; said targeting agent being connected to the labelling agent L, wherein said targeting agent comprises one or more substituted and/or unsubstituted organic ring compounds.

  本发明涉及一种非卟啉化合物或其药学上可接受的盐，适用于体外、体内和/或体外诊断和/或制药，所述化合物包括 靶向剂，用于靶向特定区域，如器官和/或组织、 用于标记目标区域的标记剂 L；所述靶向剂与标记剂 L 连接、 其中，所述靶向剂包括一种或多种取代和/或未取代的有机环化合物。
• Small molecule ice recrystallization inhibitors and methods of use thereof
  申请人：THE UNIVERSITY OF OTTAWA

  公开号：US10004222B2

  公开（公告）日：2018-06-26

  Ice recrystallization inhibitor (IRI) compounds and methods for cryopreserving umbilical cord blood are provided. The compounds are unsubstituted, mono-substituted, or di-substituted aryl-aldonamides. The methods include fractionating whole umbilical cord blood to generate a fraction comprising hematopoietic stem cells, mixing the hematopoietic stem cells with at least one IRI compound to form an IRI suspension, and freezing the IRI suspension.

  本研究提供了用于冷冻保存脐带血的冰再结晶抑制剂（IRI）化合物和方法。这些化合物是未取代的、单取代的或双取代的芳基-醛酰胺类化合物。这些方法包括分馏整个脐带血以产生包含造血干细胞的部分，将造血干细胞与至少一种IRI化合物混合以形成IRI悬浮液，并冷冻IRI悬浮液。
• van Marle, Recueil des Travaux Chimiques des Pays-Bas, 1920, vol. 39, p. 558
  作者：van Marle

  DOI：——

  日期：——
• Fischer,E.; Passmore, Chemische Berichte, 1889, vol. 22, p. 2731
  作者：Fischer,E.、Passmore

  DOI：——

  日期：——
• SMALL MOLECULE ICE RECRYSTALLIZATION INHIBITORS AND METHODS OF USE THEREOF
  申请人：THE UNIVERSITY OF OTTAWA

  公开号：US20150157010A1

  公开（公告）日：2015-06-11

  The invention relates to small molecule ice recrystallization inhibitor (IRI) compounds having increased ice recrystallization inhibition activity. The IRI compounds disclosed herein are useful in compositions, kits and methods for cryopreserving biological material such as organs, tissues and cells.