N,N-dimethylcarbamoyl-phenylsulfone | 20320-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethylcarbamoyl-phenylsulfone
• 英文别名: N,N-Dimethyl-C-phenylsulfonylformamid；N,N-Dimethyl-benzolsulfonyl-formamid；Phenyl-N,N-dimethylcarbamoylsulfon；1-(benzenesulfonyl)-N,N-dimethylformamide
• CAS: 20320-27-8
• 化学式: C₉H₁₁NO₃S
• 分子量: 213.257
• InChiKey: JHLZWWQJOMECOE-UHFFFAOYSA-N

物化性质

• 沸点：
  332.2±25.0 °C(Predicted)
• 密度：
  1.264±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-dimethylcarbamoyl-phenylsulfone 在 水 作用下， 以 四氢呋喃 为溶剂， 生成 苯磺酸
  参考文献：
  名称：

  Optimization of HNO Production from N,O-bis-Acylated Hydroxylamine Derivatives

  摘要：

  A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.

  DOI：

  10.1021/ol203016c
• 作为产物：
  描述：

  phenyl N,N-dimethyl(thiocarbamate) 在 间氯过氧苯甲酸 作用下， 生成 N,N-dimethylcarbamoyl-phenylsulfone
  参考文献：
  名称：

  Praefcke,K. et al., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1976, vol. 31b, p. 257 - 260

  摘要：

  DOI：

文献信息

• PRODUCTION PROCESS OF 2,3'-BIPYRIDYL-6'-ONE
  申请人：Sonoda Takayuki

  公开号：US20100016603A1

  公开（公告）日：2010-01-21

  A production process where 2,3′-bipyridyl-6′-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3′-bipyridyl-6′-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group.

  提供一种在工业规模下，可以在低成本且高纯度下生产2,3′-联吡啶-6′-酮的生产工艺，而无需使用昂贵的催化剂或特殊设备。生产2,3′-联吡啶-6′-酮的工艺包括将乙酰吡啶衍生物与式（II）至（V）所代表的化合物中的至少一种进行反应，合成联吡啶衍生物，然后通过一锅法水解联吡啶衍生物。在式（II）至（V）中，R2至R8、X和Y分别代表给定的基团。
• [EN] NEW TETRAHYDROPYRAZOLO[3,4-C]ISOQUINOLIN-5-AMINE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS TÉTRAHYDROPYRAZOLO[3,4-C]ISOQUINOLIN-5-AMINE
  申请人：ALMIRALL SA

  公开号：WO2010097172A1

  公开（公告）日：2010-09-02

  New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  揭示了具有化学结构式(I)的新四氢吡唑并[3,4-c]异喹啉-5-胺衍生物；以及它们的制备方法、包含它们的药物组合物和它们作为磷酸二酯酶IV（PDE4）抑制剂在治疗中的用途。
• PROCESS FOR PRODUCTION OF 2,3'-BIPYRIDYL-6'-ONE
  申请人：Fujifilm Finechemicals Co. Ltd.

  公开号：EP2123639A1

  公开（公告）日：2009-11-25

  A production process where 2,3'-bipyridyl-6'-one can be produced in high purity at low cost on an industrial scale without using an expensive catalyst or special equipment is provided. A process for producing 2,3'-bipyridyl-6'-one comprises reacting an acetylpyridine derivative with at least one of compounds represented by formulae (II) to (V) to synthesize a bipyridine derivative and hydrolyzing the bipyridine derivative by one-pot preparation. In formulae (II) to (V), each of R2 to R8, X and Y represents a given group.

  本发明提供了一种生产工艺，无需使用昂贵的催化剂或特殊设备，即可在工业规模上以低成本生产出高纯度的 2,3'-联吡啶-6'-酮。生产 2,3'-联吡啶-6'-酮的工艺包括将乙酰基吡啶衍生物与至少一种由式 (II) 至 (V) 所代表的化合物反应合成联吡啶衍生物，并通过单锅制备水解该联吡啶衍生物。在式 (II) 至 (V) 中，R2 至 R8、X 和 Y 各代表一个给定的基团。
• Nilsson,N.H. et al., Chemische Berichte, 1972, vol. 105, p. 2854 - 2871
  作者：Nilsson,N.H. et al.

  DOI：——

  日期：——
• Optimization of HNO Production from <i>N</i>,<i>O</i>-<i>bis</i>-Acylated Hydroxylamine Derivatives
  作者：Art D. Sutton、Morgan Williamson、Hilary Weismiller、John P. Toscano

  DOI：10.1021/ol203016c

  日期：2012.1.20

  A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.