2-Piperidin-1-ylacetonitrile;trifluoromethanesulfonic acid | 573987-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-Piperidin-1-ylacetonitrile;trifluoromethanesulfonic acid
• 英文别名: 2-piperidin-1-ylacetonitrile;trifluoromethanesulfonic acid
• CAS: 573987-50-5
• 化学式: C8H13F3N2O3S
• 分子量: 274.26
• InChiKey: DUSHQROJSFJSPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.37
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  93.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2018237194A1

  公开（公告）日：2018-12-27

  The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

  本公开内容提供了合成技术，包括用于立体选择性合成的试剂和方法。在某些实施例中，本公开内容提供了作为手性辅助剂有用的化合物。在某些实施例中，本公开内容提供了用于寡核苷酸合成的试剂和方法。在某些实施例中，本公开内容提供了用于手性控制寡核苷酸制备的试剂和方法。在某些实施例中，本公开内容的技术特别适用于构建具有挑战性的核苷酸间连接，提供高产率和立体选择性。
• [EN] CHIRAL PHOSPHORAMIDITE AUXILIARIES AND METHODS OF THEIR USE<br/>[FR] AUXILIAIRES DE PHOSPHORAMIDITES CHIRAUX ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SOLSTICE BIOLOGICS LTD

  公开号：WO2019006455A1

  公开（公告）日：2019-01-03

  Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them.

  本发明公开了可用于合成立体化富集的P-立体异构基团，包括P-立体异构的磷酸硫酯化合物。P-立体异构基团可以提供在核苷酸磷酸酰胺中，包括与核碱基和立体化富集的磷酸酰胺键合的糖，以及其使用方法和制备方法。
• [EN] ASYMMETRIC AUXILIARY GROUP<br/>[FR] GROUPE AUXILIAIRE ASYMÉTRIQUE
  申请人：CHIRALGEN LTD

  公开号：WO2014010250A1

  公开（公告）日：2014-01-16

  To provide a chiral reagent or a salt thereof. The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (-NO2), a halogen atom, a cyano group (-CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

  提供一个手性试剂或其盐。该手性试剂具有以下化学式（I）。在式（I）中，G1和G2独立地是氢原子，硝基（-NO2），卤素原子，氰基（-CN），式（II）或（III）的基团，或者G1和G2共同形成式（IV）的基团。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES PTE. LTD.

  公开号：US20150211006A1

  公开（公告）日：2015-07-30

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性控制的寡核苷酸、手性控制的寡核苷酸组合物以及其制备和使用方法。本发明特别涵盖了鉴定以前制备手性寡核苷酸方法中某些问题的来源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物。在某些实施例中，本发明提供了手性控制的寡核苷酸组合物。在某些实施例中，本发明提供了制备手性控制的寡核苷酸和手性控制的寡核苷酸组合物的方法。
• Chiral design
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US10160969B2

  公开（公告）日：2018-12-25

  The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

  本发明涉及精选设计的手性控制寡核苷酸、手性控制寡核苷酸组合物以及制造和使用它们的方法。在一些实施方案中，所提供的手性控制寡核苷酸组合物提供了与参考寡核苷酸组合物不同的核酸聚合物裂解模式。在一些实施方案中，所提供的手性控制寡核苷酸组合物在核酸聚合物的互补序列内提供单位点裂解。