(S)-N-(2-amino-3,3-dimethylbutyl)methanesulfonamide | 1134803-52-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (S)-N-(2-amino-3,3-dimethylbutyl)methanesulfonamide
• 英文别名: N-[(2S)-2-amino-3,3-dimethylbutyl]methanesulfonamide
• CAS: 1134803-52-3
• 化学式: C₇H₁₈N₂O₂S
• 分子量: 194.298
• InChiKey: JTDJNJPBZOHLPO-ZCFIWIBFSA-N

物化性质

• 沸点：
  288.5±42.0 °C(predicted)
• 密度：
  1.091±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.09
• 重原子数：
  12.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.19
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (1R,2S,5S)-methyl-3-((S)-3,3-dimethyl-2-((4-nitrophenoxy)carbonylamino)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate 、 (S)-N-(2-amino-3,3-dimethylbutyl)methanesulfonamide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (1R,2S,5S)-methyl-3-((S)-2-(3-((S)-3,3-dimethyl-1-(methylsulfonamido)butan-2-yl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate
  参考文献：
  名称：

  Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies

  摘要：

  Hepatitis C Virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 200 million people worldwide. Currently the only therapeutic regimens are subcutaneous interferon-alpha or PEG-interferon alone or in combination with oral ribavirin. Although combination therapy is reasonably successful with the majority of genotypes, its efficacy against the predominant genotype (genotype 1) is moderate at best, with only similar to 50% of the patients showing sustained virological response. We recently disclosed the discovery of Boceprevir, SCH 503034 (1), which is a novel, potent, selective, orally bioavailable NS3 protease inhibitor that has been shown to be efficacious in humans and is currently undergoing clinical trials. As second generation compounds, we have further explored various novel structures with the aim of improving enzyme and cellular binding activities of 1. Herein, we disclose our efforts toward the identification of a novel P-3 sulfonamide-capped inhibitor that demonstrated improved binding and cellular activity compared to 1. X-ray structure of one of these inhibitors bound to the enzyme revealed a hydrogen bond of the P-3 sulfonamide group to Cys159 which resulted in improved binding and cellular potency. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.012
• 作为产物：
  描述：

  甲基磺酰氯 、 [(2S)-1-氨基-3,3-二甲基-2-丁烷基](2-甲基-2-丙基)氨基甲酸 在 三乙胺 、 盐酸 、 水 作用下， 以 二氯甲烷 、 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 (S)-N-(2-amino-3,3-dimethylbutyl)methanesulfonamide
  参考文献：
  名称：

  Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies

  摘要：

  Hepatitis C Virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 200 million people worldwide. Currently the only therapeutic regimens are subcutaneous interferon-alpha or PEG-interferon alone or in combination with oral ribavirin. Although combination therapy is reasonably successful with the majority of genotypes, its efficacy against the predominant genotype (genotype 1) is moderate at best, with only similar to 50% of the patients showing sustained virological response. We recently disclosed the discovery of Boceprevir, SCH 503034 (1), which is a novel, potent, selective, orally bioavailable NS3 protease inhibitor that has been shown to be efficacious in humans and is currently undergoing clinical trials. As second generation compounds, we have further explored various novel structures with the aim of improving enzyme and cellular binding activities of 1. Herein, we disclose our efforts toward the identification of a novel P-3 sulfonamide-capped inhibitor that demonstrated improved binding and cellular activity compared to 1. X-ray structure of one of these inhibitors bound to the enzyme revealed a hydrogen bond of the P-3 sulfonamide group to Cys159 which resulted in improved binding and cellular potency. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.012