IPPA08 | 1231770-58-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: IPPA08
• 英文别名: 1-((6-chloropyridin-3-yl)methyl)-10-nitro-1,2,3,5,6,7,8,9-octahydro-5,9-epoxyimidazo[1,2-a]azocine；5-[(6-chloropyridin-3-yl)methyl]-7-nitro-12-oxa-2,5-diazatricyclo[6.3.1.02,6]dodec-6-ene
• CAS: 1231770-58-3
• 化学式: C₁₅H₁₇ClN₄O₃
• 分子量: 336.778
• InChiKey: XFRZOMVOLXEWIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  74.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯-5-[[(2Z)-2-(硝基亚甲基)咪唑烷-1-基]甲基]吡啶 、 戊二醛 在 盐酸 作用下， 以 水 、 乙腈 为溶剂， 以86%的产率得到IPPA08
  参考文献：
  名称：

  HETEROCYCLIC NITROGENOUS OR OXYGENOUS COMPOUNDS WITH INSECTICIDAL ACTIVITY FORMED FROM DIALDEHYDES AND THEIR PREPARATION AND USES THEREOF

  摘要：

  提供了由二醛形成的具有化学式(A)、(B)、(C)或(D)的杂环氮或氧化合物，它们的光学异构体、顺式和反式异构体，或者农药可接受的盐，它们的制备方法，包括这些化合物的农药组合物以及它们的用途。这些化合物及其衍生物对几种农业和林业害虫具有高杀虫活性，包括同翅目和鳞翅目害虫，如蚜虫、蝉总科昆虫、烟粉虱、叶蝉、普通飞虱、棉铃虫、甘蓝青虫、甘蓝蛾、棉叶螟、军虫等。

  公开号：

  US20110269751A1

文献信息

• Heterocyclic nitrogenous or oxygenous compounds with insecticidal activity formed from dialdehydes and their preparation and uses thereof
  申请人：Li Zhong

  公开号：US08563546B2

  公开（公告）日：2013-10-22

  The heterocyclic nitrogenous or oxygenous compounds of formula (A), (B), (C) or (D) formed from dialdehydes, their optical isomers, cis- and trans-isomers, or agrochemically acceptable salts, their preparation methods, agrochemical compositions comprising the compounds and the uses thereof are provided. The compounds and their derivatives have high insecticidal activities to several farming and forestry pests including homoptera and lepidoptera pests, such as aphis, fulgorid, whitefly, leafhopper, common thrips, cotton bollworm, cabbage caterpillar, cabbage moth, cotton leafworm, armyworm and so on.

  提供由二醛(A)、(B)、(C)或(D)形成的杂环氮或氧化合物，它们的光学异构体、顺反异构体或农药可接受的盐，它们的制备方法，包括这些化合物的农药组成物及其用途。这些化合物及其衍生物对几种农林害虫具有高度的杀虫活性，包括同翅目和鳞翅目害虫，如蚜虫、叶蝉、白粉虱、飞虱、普通蓟马、棉铃虫、卷叶蛾、甘蓝蛾、棉叶虫、斜纹夜蛾等。
• Design, Synthesis, Crystal Structures, and Insecticidal Activities of Eight-Membered Azabridge Neonicotinoid Analogues
  作者：Renbo Xu、Rui Xia、Ming Luo、Xiaoyong Xu、Jiagao Cheng、Xusheng Shao、Zhong Li

  DOI：10.1021/jf4046683

  日期：2014.1.15

  Three series of novel azabridge neonicotinoid analogues were designed and synthesized, which were constructed by starting material A, glutaraldehyde, and primary amine hydrochlorides (aliphatic amines, phenylhydrazines, and anilines). Most of the eight-membered azabridge compounds presented higher insecticidal activities than oxabridged compound B against cowpea aphid (Aphis craccivora) and brown planthopper (Nilaparvata lugens). Compared with imidacloprid, some azabridged compounds exhibited excellent insecticidal activity against brown planthopper. The crystal structures and bioassay indicated that changing bridge atoms from O to N could lead to entirely different conformations, which might be the important influential factor of the bioactivities.
• US8563546B2
  申请人：——

  公开号：US8563546B2

  公开（公告）日：2013-10-22
• HETEROCYCLIC NITROGENOUS OR OXYGENOUS COMPOUNDS WITH INSECTICIDAL ACTIVITY FORMED FROM DIALDEHYDES AND THEIR PREPARATION AND USES THEREOF
  申请人：East China University of Science and Technology

  公开号：EP2377845B1

  公开（公告）日：2015-01-28