bis(2-hydroxypropyl) fumarate | 10095-17-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bis(2-hydroxypropyl) fumarate
• 英文别名: di-(2-hydroxypropyl) fumarate；bis-(2-hydroxypropyl) fumarate；di(2-hydroxylpropyl) fumarate；2-Hydroxy propyl fumarate；bis(2-hydroxypropyl) (E)-but-2-enedioate
• CAS: 10095-17-7
• 化学式: C₁₀H₁₆O₆
• 分子量: 232.233
• InChiKey: ADYMVDABNYGGSL-ONEGZZNKSA-N

物化性质

• 沸点：
  388.5±32.0 °C(Predicted)
• 密度：
  1.222±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  bis(2-hydroxypropyl) fumarate 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 fumaric acid bis(2-acryloyloxy propyl) ester
  参考文献：
  名称：

  Characterization of the Cross-Linked Structure of Fumarate-Based Degradable Polymer Networks

  摘要：

  A new method was developed to examine networks formed with linear macromers of fumaric acid and diacrylate cross-linking agents in order to analyze their cross-linked structure. This method involved the accelerated degradation of the networks and the analysis of the degradation products. Two model networks of poly(propylene fumarate) (PPF) cross-linked with poly(propylene fumarate)-diacrylate (PPF-DA) and oligo(poly(ethylene glycol) fumarate) (OPF) cross-linked with poly(ethylene glycol)-diacrylate (PEG-DA) were evaluated with this method to determine the macromer and cross-linking agent conversions, the network cross-linking density, and an estimate of the molecular weight between cross-links. The validity of the method was confirmed by the analysis of the composition of the un-cross-linked macromers and the correlation of the mechanical properties of the cross-linked polymers with the macromer/cross-linking agent double bond ratio. The results showed that acrylate species had participated more than fumarates in network formation. Furthermore, the structure of PPF/PPF-DA networks was influenced by the amount of cross-linking agent in the polymer formulation, and the OPF/PEG-DA network structure was controlled by the number of repeating fumarate units in the macromer. This method provides a new means to characterize the macromolecular structure of fumarate-based networks.

  DOI：

  10.1021/ma020028q
• 作为产物：
  描述：

  1,2-丙二醇 、 富马酸二乙酯 在 对苯二酚 、 zinc(II) chloride 作用下， 反应 8.0h， 生成 bis(2-hydroxypropyl) fumarate
  参考文献：
  名称：

  聚（富马酸丙二酯）和聚（ε-己内酯）组成的可生物降解和可交联的多嵌段共聚物：合成，表征和物理性质

  摘要：

  为了开发各种可控的生物材料，通过低聚物的三步缩聚反应，合成了一系列新型的可交联和可生物降解的多嵌段聚富马酸丙烯-共己内酯共聚物[P（PF - co -CL）]共聚物。聚富马酸丙二醇酯（PPF）和聚己内酯（PCL）二醇。通过FTIR，1 H NMR和13 C NMR光谱进一步表征了15种具有不同PCL组成和链段长度的共聚物的化学结构。它们的物理和流变性质已被广泛确定。各种特征温度（例如玻璃化转变温度T g，熔融温度T）的成分依赖性使用相图对m，热降解温度T d进行了说明。连同DSC结果，几种具有高PCL组成的共聚物的偏光光学显微镜图显示了球晶的晶体结构。当在室温下结晶时，特别发现对于PCL组成为87％的共聚物而言，带状球晶。当这些共聚物中的PCL组成低于70％时，该共聚物是具有降低的T g的无定形的。这对于提高生物降解速度至关重要。由于共聚物中PCL链段的柔性，P（PF- co-CL）可以是

  DOI：

  10.1021/ma050884c

文献信息

• Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers
  作者：Shimon Ben‐Shabat、Omar Elmalak、Abraham Nyska、Abraham J. Domb

  DOI：10.1560/edr4-8fc1-cq8m-j6rl

  日期：2005.9

  A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters

  制备了一系列由富马酸，琥珀酸和丙二醇的三聚体构成的新的可生物降解的共聚物和共聚酸酐，其涵盖了广泛的组成范围，并被表征用作药物载体。发现聚合物在数周内降解。载有布洛芬作为模型药物的聚酐将药物释放持续一周，而聚酯则将药物释放持续30天以上。在大鼠中研究了富马酸和琥珀酸基于三聚体的聚合物的生物相容性和排空速率。当植入小鼠体内时，发现所有聚合物都是相容的。
• PARABEN DERIVATIVES FOR PRESERVING CELLULOSIC MATERIALS
  申请人：CARLSON William B.

  公开号：US20130004785A1

  公开（公告）日：2013-01-03

  A method of preserving a cellulosic material are provided. The method includes contacting the cellulosic material with a paraben-containing monomer and polymerizing the paraben-containing monomer. Articles including a cellulosic material and at least one polymer which includes paraben moieties are also provided.

  提供了一种保存纤维素材料的方法。该方法包括将纤维素材料与含对羟基苯甲酸酯单体接触，并聚合含有对羟基苯甲酸酯单体的聚合物。还提供了包括纤维素材料和至少一种包含对羟基苯甲酸酯基团的聚合物的制品。
• Biocompatible macromers
  申请人：——

  公开号：US20020028189A1

  公开（公告）日：2002-03-07

  A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerization in the presence of either a chemical or photo initiator. A cross-linked OPF gel has a swelling behavior that is tunable dependent on the molecular weight of PEG. A cross-linkable PEG macromer, as exemplified by oligo(PEG fumarate), has unsaturated double bonds, for example in the fumaryl groups, along its macromolecular chain that allows for the preparation of hydrogels with tailored structure and properties.

  基于交替富马酸和聚乙二醇（PEG）单元的新寡聚物已提供。该寡聚物（PEG富马酸酯）（OPF）可以通过修饰与生物相容的有机基团进行官能化。此外，OPF可以在化学或光引发剂的存在下通过自由基聚合进行交联。交联的OPF凝胶具有可调节的膨胀行为，取决于PEG的分子量。例如，交联的PEG大分子单体，如寡聚（PEG富马酸酯），其大分子链上具有不饱和双键，例如在富马酰基团中，这允许制备具有定制结构和性质的水凝胶。
• ADHESIVE COMPOSITION
  申请人：ZEON CORPORATION

  公开号：US20150225618A1

  公开（公告）日：2015-08-13

  An adhesive composition containing a latex of a highly saturated nitrile rubber (A) which has α,β-ethylenically unsaturated nitrile monomer units 10 to 55 wt %, conjugated diene monomer units 25 to 89 wt %, and α,β-ethylenically unsaturated dicarboxylic acid monoester monomer units 1 to 20 wt % and has an iodine value of 120 or less and a polyvalent amine compound (B).

  一种黏合剂组合物，包含高度饱和丙烯腈橡胶（A）的乳液，其中α，β-乙烯基不饱和丙烯腈单体单位占10至55重量％，共轭二烯单体单位占25至89重量％，α，β-乙烯基不饱和二羧酸单酯单体单位占1至20重量％，并且具有碘值不超过120和多价胺化合物（B）。
• Thermoplastic polyester resin stretched film
  申请人：OJI-YUKA SYNTHETIC PAPER CO., LTD.

  公开号：EP0786495A2

  公开（公告）日：1997-07-30

  A stretched resin film having as a base material a resin composition composed of the following components (A), (B), (C) and (D): (A) a thermoplastic polyester resin    100 parts by weight; (B) a modified olefin based resin obtained by graft polymerizing 0.01 to 20 parts by weight of an α,β-unsaturated carboxylate based monomer having a hydroxyl group and 0.01 to 50 parts by weight of an aromatic vinyl compound onto 100 parts by weight of an olefin based resin    3 to 100 parts by weight; (C) a polyethylene resin having a molecular weight of 1,000 to 10,000    1 to 10 parts by weight; and (D) a bisphenol epoxy resin    1 to 10 parts by weight.

  一种拉伸树脂薄膜，其基料是由以下成分（A）、（B）、（C）和（D）组成的树脂组合物： (A) 热塑性聚酯树脂 按重量计为 100 份； (B) 一种改性烯烃基树脂，它是通过将 0.01 至 20 份（重量份）具有羟基的 α，β-不饱和羧酸基单体和 0.01 至 50 份（重量份）芳香族乙烯基化合物接枝聚合到 100 份（重量份）烯烃基树脂上而得 3 至 100 份(重量)； (C) 聚乙烯树脂，其分子量为 1,000 至 10,000 1 至 10 份(重量)；及 (D) 双酚环氧树脂 1 至 10 份（重量比）。