1-(4-fluorophenyl)-1-(4-(N-morpholino)phenyl)prop-2-yn-1-ol | 1309957-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-fluorophenyl)-1-(4-(N-morpholino)phenyl)prop-2-yn-1-ol
• 英文别名: 1-(4-Fluorophenyl)-1-(4-morpholin-4-ylphenyl)prop-2-yn-1-ol；1-(4-fluorophenyl)-1-(4-morpholin-4-ylphenyl)prop-2-yn-1-ol
• CAS: 1309957-23-0
• 化学式: C₁₉H₁₈FNO₂
• 分子量: 311.356
• InChiKey: PXFINLBPUQBNLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-fluorophenyl)-1-(4-(N-morpholino)phenyl)prop-2-yn-1-ol 、 10-bromo-7-butyl-7-methyl-3-(trifluoromethyl)-7H-benzo[c]fluoren-5-ol 在 对甲苯磺酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 4.0h， 生成 3-(4-fluorophenyl)-3-(4-(N-morpholino)phenyl)-10-bromo-6-trifluoromethyl-13-methyl-13-butyl-3H,13H-indeno[2',3':3,4]naphtho[1,2-b]pyran
  参考文献：
  名称：

  METHODS OF MAKING FUSED RING COMPOUNDS

  摘要：

  本发明涉及制备融合环化合物的方法，例如吲哚并螺酚和融合环吲哚吡喃化合物，例如吲哚并萘吡喃，每种方法都使用以下化合物II表示的不饱和化合物。关于化合物II的不饱和化合物：环-A可以选择从可选取代芳基（例如苯基）中选择；m可以例如从0到4；每个m的R1可以选择从可选取代的碳氢化合物（例如C1-C6烷基），可选地中断至少一个连接基（例如-O-）；R3和R16可以各自独立地选择，例如氢或可选取代的碳氢化合物，例如C1-C8烷基。当环-A是苯基时，由化合物II表示的不饱和化合物可以称为不饱和吲哚酮酸/酯化合物或吲哚酮酸/酯化合物（取决于R16是氢还是可选取代的碳氢基团）。

  公开号：

  US20120157678A1

文献信息

• Method Of Preparing Fused Ring Indeno Compounds
  申请人：Transitions Optical, Inc.

  公开号：US20150141662A1

  公开（公告）日：2015-05-21

  The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride. With some embodiments, the fused ring indeno compound is represented by the following Formula (I-A), the dienophile is represented by the following Formula (II-A), and the lactone compound is represented by the following Formula (III-A):

  本发明涉及一种制备融合环吲哚化合物的方法，涉及将双亲受体和内酯化合物在催化剂和羧酸酐的存在下反应在一起。在某些实施例中，融合环吲哚化合物由以下式(I-A)表示，双亲受体由以下式(II-A)表示，内酯化合物由以下式(III-A)表示：
• [EN] INDOLONAPHTHOPYRANS<br/>[FR] INDOLONAPHTOPYRANES
  申请人：TRANSITIONS OPTICAL LTD

  公开号：WO2020126032A1

  公开（公告）日：2020-06-25

  Provided is a photochromic indolenaphthopyran compound having the skeletal structure of Formula (I): wherein R1 and R2 each independently have a steric bulk A, wherein at least one of R1 or R2 has a steric bulk A of at least 0.6, R3 and R4 each independently have a Hammett σρ value, and wherein the indolenaphthopyran compound has a calculated electronic steric factor of at least -3.3.

  提供的是一种具有式（I）的骨架结构的光致变色吲哚萘吡喃化合物：其中R1和R2各自独立地具有一个立体体积A，其中R1或R2中至少有一个具有至少0.6的立体体积A，R3和R4各自独立地具有一个Hammett σρ值，并且该吲哚萘吡喃化合物具有至少-3.3的计算电子立体因子。
• LACTONE COMPOUNDS AND MATERIALS MADE THEREFROM
  申请人：He Meng

  公开号：US20120157677A1

  公开（公告）日：2012-06-21

  The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).

  本发明涉及以下I和II式所代表的内酯化合物及其制备方法。本发明还涉及从这些内酯化合物制备其他材料的方法，例如融合环吲哚酚化合物（例如吲哚融合萘酚）和融合环吲哚吡喃化合物（例如吲哚融合萘吡喃）。
• Photochromic indeno-fused naphthopyrans
  申请人：Chopra Anu

  公开号：US20070138448A1

  公开（公告）日：2007-06-21

  Photochromic materials comprising indeno-fused naphthopyrans having substituents comprising a 4-fluorophenyl group and a 4-aminophenyl group bonded to the 3-position of the indeno-fused naphthopyran are disclosed. The photochromic materials may exhibit faster fade rates as compared to similar indeno-fused naphthopyrans without a 4-fluorophenyl group and a 4-aminophenyl group bonded to the 3-position of the indeno-fused naphthopyran. Substituted 2-propyn-1-ols utilized for the synthesis of the indeno-fused naphthopyrans disclosed herein are disclosed. Photochromic compositions and articles, such as optical elements, incorporating the photochromic materials disclosed herein are also disclosed.

  本文披露了一种包含取代基的吲哚并萘噻吩的光致变色材料，该取代基包括与吲哚并萘噻吩的3位键合的4-氟苯基和4-氨基苯基。与没有4-氟苯基和4-氨基苯基键合到吲哚并萘噻吩的类似吲哚并萘噻吩相比，光致变色材料可能表现出更快的褪色速率。本文还披露了用于合成本文所披露的吲哚并萘噻吩的取代2-丙炔-1-醇。本文还披露了包含本文所披露的光致变色材料的光致变色组合物和物品，例如光学元件。
• Methods of making fused ring compounds
  申请人：Transitions Optical, Inc.

  公开号：US10689317B2

  公开（公告）日：2020-06-23

  The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C1-C6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R3 and R16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C1-C8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R16 is hydrogen, or an optionally substituted hydrocarbyl group).

  本发明涉及制造熔融环化合物（如茚并熔合萘酚）和熔融环茚并吡喃化合物（如茚并熔合萘并吡喃）的方法，其中每种化合物都采用下式 II 所代表的不饱和化合物。 关于式 II 的不饱和化合物：环-A 可以选自任选取代的芳基（如苯基）；m 可以是例如 0 至 4；每个 m 的 R1 可以选自任选取代的烃基（如 C1-C6 烷基），任选与至少一个连接基团（如 -O-）间断；R3 和 R16 可以各自独立地选自例如氢或任选取代的烃基，如 C1-C8 烷基。当环-A 为苯基时，式 II 所代表的不饱和化合物可称为不饱和茚酮酸/酯化合物或茚酮酸/酯化合物（取决于 R16 是氢还是任选取代的烃基）。