(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydroiodide | 118444-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;dihydroiodide
• CAS: 118444-00-1
• 化学式: C23H26I2N6O5S2
• 分子量: 784.4
• InChiKey: LZYSKVDSBSOVMC-HVYPILMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.58
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  208
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• METHOD OF MAKING CEFQUINOME PARTICLES
  申请人：Intervet International B.V.

  公开号：EP2456775A1

  公开（公告）日：2012-05-30
• USE OF LIQUID MEDIUM EXCHANGE BY CROSS FLOW FILTRATION IN THE PREPARATION OF DRUG SUSPENSIONS
  申请人：Intervet International B.V.

  公开号：EP2663287A1

  公开（公告）日：2013-11-20
• US9066864B2
  申请人：——

  公开号：US9066864B2

  公开（公告）日：2015-06-30
• [EN] METHOD OF MAKING CEFQUINOME PARTICLES<br/>[FR] MÉTHODE DE FABRICATION DE PARTICULES DE CEFQUINOME
  申请人：INTERVET INT BV

  公开号：WO2011009827A1

  公开（公告）日：2011-01-27

  Disclosed is a process for the production of particles of a cefquinome acid addition salt, preferably cefquinome sulfate particles, by precipitation of cefquinome acid addition salt, preferably the sulfate, from a cefquinome betaine solution, wherein acid, preferably sulfuric acid, is added to the betaine solution. According to the invention the acid, preferably sulfuric acid, is added quickly in a single shot, in a molar excess of 40% to less than 100%. As a result, particles are formed that comprise agglomerates of microscale primary crystalline particles. This enables providing particles of cefquinome acid addition salt, preferably cefquinome sulfate, in particle sizes commensurate with micronized material, but with improved stability.
• [EN] USE OF LIQUID MEDIUM EXCHANGE BY CROSS FLOW FILTRATION IN THE PREPARATION OF DRUG SUSPENSIONS<br/>[FR] UTILISATION D'ÉCHANGE DE MILIEU LIQUIDE PAR FILTRATION À CONTRECOURANT DANS LA PRÉPARATION DE SUSPENSIONS DE MÉDICAMENT
  申请人：INTERVET INT BV

  公开号：WO2012095439A1

  公开（公告）日：2012-07-19

  Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.