申请人:Walter Mary Ann
公开号:US20100184866A1
公开(公告)日:2010-07-22
Compounds are provided herein which are coordination complexes of the formula, A
x
B
y
Cit
2
F
z
.mH
2
O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.
本文提供的化合物是配位化合物,化学式为AxByCit2Fz.mH2O,其中A是周期表中某些IA或IIA金属离子中选择的阳离子;B是从某些IIA金属离子和某些二价d-块过渡金属离子中选择的阳离子;A和B是不同的;“Cit”是三碱性柠檬酸根离子;x到y的化学计量比大于或等于1.0但小于8.0;m为0-12;z被选择以保持电中性。本文提供的化合物可用于治疗膳食缺乏、骨质疏松症、骨质疏松症、骨质流失以及骨质流失风险,以及其他需要给予各种离子的医疗情况。此外,这些化合物可用作牙科用氟化物来源,用于氟化水系统。