N-cynnamylhexamethyleneimine | 571246-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cynnamylhexamethyleneimine
• 英文别名: trans-3-Hexamethylenimino-1-phenylprop-1-en；1-Cinnamylazepane；1-[(E)-3-phenylprop-2-enyl]azepane
• CAS: 571246-03-2
• 化学式: C₁₅H₂₁N
• 分子量: 215.338
• InChiKey: ACLWQZLLZUBDMJ-DHZHZOJOSA-N

物化性质

• 沸点：
  336.4±21.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.466
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-cynnamylhexamethyleneimine 、 苯 在 三氟甲磺酸 作用下， 反应 3.0h， 以88%的产率得到普罗扎平
  参考文献：
  名称：

  Dicationic Electrophiles from Olefinic Amines in Superacid

  摘要：

  This paper describes the superacid-catalyzed chemistry of olefinic amines and related compounds. A variety of olefinic amines are found to react with benzene in CF3SO3H (triflic acid) to give addition products in good yields (75-99%), including the pharmaceutical agents fenpiprane and prozapine. A general mechanism is proposed that invokes the formation of reactive, dicationic electrophiles and the direct observation of a diprotonated species is reported from low-temperature NMR experiments. This chemistry is also used to conveniently prepare functionalized polystyrene beads having pendant amine groups.

  DOI：

  10.1021/jo030024z
• 作为产物：
  描述：

  环己亚胺 、 肉桂基氯 以 环己烷 为溶剂， 反应 24.0h， 以68%的产率得到N-cynnamylhexamethyleneimine
  参考文献：
  名称：

  Preparation of functionalized anionic polymerization initiators

  摘要：

  一种制备功能化聚合引发剂的方法，包括将功能化的苯乙烯化合物和有机锂化合物混合。

  公开号：

  US20060036050A1

文献信息

• ADENYLYL CYCLASE INHIBITORS FOR NEUROPATHIC AND INFLAMMATORY PAIN
  申请人：Purdue Research Foundation

  公开号：US20160272572A1

  公开（公告）日：2016-09-22

  The invention generally relates to adenylyl cyclase inhibitor compounds and methods for treating neuropathic or inflammatory pain by using those compounds.

  这项发明通常涉及腺苷酸环化酶抑制剂化合物及利用这些化合物治疗神经病理性或炎症性疼痛的方法。
• Dicationic Electrophiles from Olefinic Amines in Superacid
  作者：Yun Zhang、Aaron McElrea、Gregorio V. Sanchez、Dat Do、Alma Gomez、Sharon L. Aguirre、Rendy、Douglas A. Klumpp

  DOI：10.1021/jo030024z

  日期：2003.6.1

  This paper describes the superacid-catalyzed chemistry of olefinic amines and related compounds. A variety of olefinic amines are found to react with benzene in CF3SO3H (triflic acid) to give addition products in good yields (75-99%), including the pharmaceutical agents fenpiprane and prozapine. A general mechanism is proposed that invokes the formation of reactive, dicationic electrophiles and the direct observation of a diprotonated species is reported from low-temperature NMR experiments. This chemistry is also used to conveniently prepare functionalized polystyrene beads having pendant amine groups.
• Preparation of functionalized anionic polymerization initiators
  申请人：Antkowiak Thomas

  公开号：US20060036050A1

  公开（公告）日：2006-02-16

  A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.

  一种制备功能化聚合引发剂的方法，包括将功能化的苯乙烯化合物和有机锂化合物混合。