1,6-dichloropyridazine | 947372-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,6-dichloropyridazine
• 英文别名: 1,6-Dichloropyridazine；2,3-dichloro-1H-pyridazine
• CAS: 947372-29-4
• 化学式: C₄H₄Cl₂N₂
• 分子量: 150.995
• InChiKey: BNOKXUQLZYICOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3R,4R,5S)-1-{[(3S,4S)-4-(5-chloropyridin-2-yl)pyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol 、 1,6-dichloropyridazine 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以42%的产率得到(3R,4R,5S)-1-{[(3S,4S)-1-(6-chloropyridazin-3-yl)-4-(5-chloropyridin-2-yl)pyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol
  参考文献：
  名称：

  WO2007/96763

  摘要：

  公开号：

文献信息

• [EN] SUBSTITUTED 1,4-DITHIINE DERIVATIVES AND THEIR USE AS FUNGICIDES<br/>[FR] DÉRIVÉS DE 1,4-DITHIINE SUBSTITUÉS ET LEUR UTILISATION COMME FONGICIDES
  申请人：BASF SE

  公开号：WO2015150138A1

  公开（公告）日：2015-10-08

  The present invention relates to substituted thiadiazoles and the salts thereof and the use of these compounds for combating phytopathogenic fungi, and to seeds coated with at least one such compound.

  本发明涉及替代噻二唑及其盐以及利用这些化合物对抗植物病原真菌，以及涂覆至少一种这样化合物的种子。
• Melanocortin Type 4 Receptor Agonist Piperidinoylpyrrolidines
  申请人：Andrews Mark David

  公开号：US20090036459A1

  公开（公告）日：2009-02-05

  The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

  本发明涉及一类黑色素细胞激素MCR4激动剂，其一般式为（I），其中变量和取代基如本文所定义，特别是选择性MCR4激动剂化合物，它们在医学上的用途，特别是在性功能障碍和肥胖症的治疗中，以及在其合成中有用的中间体和含有它们的组合物。
• PIPERIDINOYLPYRROLIDINES AS MELANOCORTIN TYPE 4 RECEPTOR AGONISTS
  申请人：Pfizer Limited

  公开号：EP1989196B1

  公开（公告）日：2013-02-13
• US8138188B2
  申请人：——

  公开号：US8138188B2

  公开（公告）日：2012-03-20
• [EN] COMPOUND LIBRARIES OF 2,3-SUBSTITUTED PYRAZINE DERIVATIVES CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS<br/>[FR] BIBLIOTHEQUES DE COMPOSES DE DERIVES DE PYRAZINE 2,3-SUBSTITUES POUVANT SE FIXER AUX RECEPTEURS COUPLES A LA PROTEINE G
  申请人：BIOFOCUS PLC

  公开号：WO2004058265A1

  公开（公告）日：2004-07-15

  The present invention provides a compound library designed to pick up interactions with receptors for a subset of peptidic receptors, especially those with recognition sites for amide and acidic ligands based around TM3 and TM6. The presence of the amide-acid recognition site here is a consequence of the requirements for binding the natural ligands either with C-terminal regions or with the backbone of peptide loops. The library comprises or consists of a set of structurally related compounds of the following general formulae: formula (A) formula (B) formula (C) formula (D1).