PROCESS FOR THE PREPARATION OF PYRIDO[2,1-A]ISOQUINOLINE DERIVATIVES
申请人:F. Hoffmann-La Roche AG
公开号:EP2234997B1
公开(公告)日:2012-09-05
US8420818B2
申请人:——
公开号:US8420818B2
公开(公告)日:2013-04-16
PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES
申请人:Abrecht Stefan
公开号:US20090163718A1
公开(公告)日:2009-06-25
The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula
wherein R
2
, R
3
and R
4
are each independently selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy and lower alkenyl, wherein lower alkyl, lower alkoxy and lower alkenyl may optionally be substituted by a group consisting of lower alkoxycarbonyl, aryl and heterocyclyl, and the pharmaceutically acceptable salts thereof. The pyrido[2,1-a]isoquinoline derivatives of the formula I are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.