(S)-1-palmitoyl-2-linoleoyl-3-acetyl glycerol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (S)-1-palmitoyl-2-linoleoyl-3-acetyl glycerol
• 英文别名: (S)-1-palmitoyl-2-linoleyl-3-acetyl-glycerol；(S)-1-palmitoyl-2-linoleoyl-3-acetyl-glycerol；[(2S)-1-acetyloxy-3-hexadecanoyloxypropan-2-yl] (9Z,12Z)-octadeca-9,12-dienoate
• 化学式: C₃₉H₇₀O₆
• 分子量: 634.981
• InChiKey: GAKUNXBDVGLOFS-INJBRAEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  45
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-palmitoyl-2-linoleyl-3-trityl-glycerol 、 (S)-1-palmitoyl-2-linoleoyl-3-acetyl glycerol 以(R)-1-palmitoyl-2-linoleoyl-3-acetyl-glycerol (45.8 g) were obtained in the same manner的产率得到(R)-1-palmitoyl-2-linoleoyl-3-acetylglycerol
  参考文献：
  名称：

  Preparation of glycerol derivatives ad intermediates therefor

  摘要：

  本发明公开了一种高效高产的甘油衍生物区域选择性制备方法。该区域选择性制备1-R1-2-R2-3-乙酰基甘油衍生物的方法包括以下步骤：通过在1-R1-甘油的3位引入保护基，获得1-R1-3-保护基-甘油；通过在1-R1-3-保护基-甘油的2位引入R2基团，获得1-R1-2-R2-3-保护基-甘油；同时进行去保护反应和乙酰化反应，制备1-R1-2-R2-3-保护基-甘油衍生物。其中，R1和R2是具有16到22个碳原子的脂肪酸基团，且彼此不同；保护基为三苯甲基基团或三烷基硅基团。

  公开号：

  US20090253923A1

文献信息

• Preparation of glycerol derivatives and intermediates therefor
  申请人：Enzychem Co., Ltd.

  公开号：US07868196B2

  公开（公告）日：2011-01-11

  Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R1-3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R1-glycerol; obtaining 1-R1-2-R2-3-protecting group-glycerol by introducing R2 group into 2-position of 1-R1-3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R1-2-R2-3-protecting group-glycerol at the same time. Wherein, R1 and R2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

  本发明揭示了一种高效率和高产率的选择区域性制备甘油衍生物的方法。该方法包括以下步骤：通过在1-R1-甘油的3位引入保护基获得1-R1-3-保护基-甘油；通过在1-R1-3-保护基-甘油的2位引入R2基团获得1-R1-2-R2-3-保护基-甘油；同时进行去保护反应和乙酰化反应，以制备1-R1-2-R2-3-乙酰基-甘油衍生物。其中，R1和R2是具有16到22个碳原子的脂肪酸基团，且彼此不同；保护基为三苯甲基基团或三烷基基团。
• PREPARATION OF GLYCEROL DERIVATIVES AND INTERMEDIATES THEREFOR
  申请人：Enzychem Co., Ltd.

  公开号：EP1907345B1

  公开（公告）日：2009-10-21
• US7868196B2
  申请人：——

  公开号：US7868196B2

  公开（公告）日：2011-01-11
• Preparation of glycerol derivatives ad intermediates therefor
  申请人：Lee Tae-Suk

  公开号：US20090253923A1

  公开（公告）日：2009-10-08

  Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R 1 -2-R 2 -3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R 1 -3-protecting group-glycerol by introducing a protecting group to 3-position of 1-R 1 -glycerol; obtaining 1-R 1 -2-R 2 -3-protecting group-glycerol by introducing R 2 group into 2-position of 1-R 1 -3-protecting group-glycerol; and carrying out the deprotection reaction and the acetylation reaction of 1-R 1 -2-R 2 -3-protecting group-glycerol at the same time. Wherein, R 1 and R 2 are fatty acid groups having 16 to 22 carbon atoms, and are different from each other; and the protecting group is trityl group or trialkylsilyl group.

  揭示了一种高效率和高产率的选择性区域制备甘油衍生物的过程。制备1-R1-2-R2-3-乙酰基甘油衍生物的选择性区域制备过程包括以下步骤：通过在1-R1-甘油的3位引入保护基获得1-R1-3-保护基-甘油；通过在1-R1-3-保护基-甘油的2位引入R2基获得1-R1-2-R2-3-保护基-甘油；同时进行1-R1-2-R2-3-保护基-甘油的去保护反应和乙酰化反应。其中，R1和R2是具有16至22个碳原子的脂肪酸基团，且彼此不同；保护基为三苯基基团或三烷基硅基团。