Oxalate;trimethyl(tetradecyl)azanium | 154858-16-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxalate;trimethyl(tetradecyl)azanium
• 英文别名: oxalate;trimethyl(tetradecyl)azanium
• CAS: 154858-16-9
• 化学式: C19H38NO4-
• 分子量: 344.5
• InChiKey: IASNHTVFXYNISW-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.88
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method to quantify in vivo RNA levels
  申请人：Cypro S.A.

  公开号：EP1329506A1

  公开（公告）日：2003-07-23

  The invention in particular relates to a method for the quantification of in vivo RNA from a biological sample comprising the steps of: collecting said biological sample in a tube comprising a compound inhibiting RNA degradation and/or gene induction; forming a precipitate comprising nucleic acids; separating said precipitate from the supernatant; dissolving said precipitate using a buffer, forming a suspension; isolating nucleic acids from said suspension using an automated device; dispersing/distributing a reagent mix for RT-PCR using an automated device; dispersing/distributing the isolated nucleic acids within the dispersed reagent mix using an automated device, and, determining the in vivo levels of transcripts using the nucleic acid/RT-PCR reagent mix in an automated setup.The present invention also relates to the quantification of DNA from a biological sample. The present invention further elucidates a kit for isolating quantifiable nucleic acids from a biological sample. Applications of the method according to present invention are also disclosed.

  本发明尤其涉及一种从生物样本中定量检测体内 RNA 的方法，包括以下步骤在含有抑制 RNA 降解和/或基因诱导的化合物的试管中收集所述生物样品；形成包含核酸的沉淀；从上清液中分离所述沉淀；使用缓冲液溶解所述沉淀，形成悬浮液；使用自动装置从所述悬浮液中分离核酸；使用自动装置分散/分配用于 RT-PCR 的混合试剂；使用自动装置在分散的混合试剂中分散/分配分离的核酸，以及，在自动设置中使用核酸/RT-PCR 混合试剂确定转录物的体内水平。本发明还涉及生物样本中 DNA 的定量。本发明进一步阐明了一种从生物样本中分离可定量核酸的试剂盒。还公开了根据本发明的方法的应用。
• ZUSAMMENSETZUNG ZUR DESINFEKTION UND FÜR KOSMETISCHE ANWENDUNGEN
  申请人：Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

  公开号：EP4088784A1

  公开（公告）日：2022-11-16

  Die vorliegende Erfindung betrifft eine wässrige Zusammensetzung zur Desinfektion und für kosmetische Anwendungen, ihre Verwendung und ein Verfahren zu ihrer Herstellung.

  本发明涉及一种用于消毒和化妆品的水性组合物、其用途及其制备工艺。
• Stabilizing compositions and methods for extraction of ribonucleic acid
  申请人：DNA Genotek Inc.

  公开号：US10000795B2

  公开（公告）日：2018-06-19

  The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is used in methods for extracting and storing ribonucleic acid from the biological sample.

  本发明提供了一种稳定生物样品中核糖核酸（RNA）的组合物和方法，使样品中的核糖核酸在室温下保持稳定。该组合物由阴离子洗涤剂和缓冲剂组成，pH 值约为 5 至 8.2，可用于从生物样本中提取和储存核糖核酸的方法。
• Red blood cell lysis solution
  申请人：Gen-Probe Incorporated

  公开号：US10093989B2

  公开（公告）日：2018-10-09

  The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

  本发明提供一种裂解试剂，用于裂解红细胞，从而以适合分析的形式释放目标物，如寄生生物的 RNA。该试剂至少包括氯化铵和阴离子洗涤剂，还可包括抗凝剂。试剂的作用是裂解红细胞，保护释放的靶标在裂解液中不被降解，并与随后的靶标分析步骤兼容，如靶标捕获、扩增、检测或测序。
• Determination of platelet-miRNAs in alzheimer's disease
  申请人：Hummingbird Diagnostics GmbH

  公开号：US10815527B2

  公开（公告）日：2020-10-27

  The present invention relates to methods, kits and uses for determining platelet-miRNAs in a from a platelet-comprising fraction derived from a whole blood sample from a subject affected or suspected to be affected by Alzheimer's Disease.

  本发明涉及从受阿尔茨海默病影响或疑似受阿尔茨海默病影响的受试者的全血样本中提取的含有血小板的部分中确定血小板-miRNA 的方法、试剂盒和用途。