galloyloxy-acetic acid | 50888-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: galloyloxy-acetic acid
• 英文别名: (3.4.5-Trioxy-benzoyl)-glykolsaeure；Galloyloxy-essigsaeure；Galloylglykolsaeure；Galloylglycollinsaeure；2-(3,4,5-Trihydroxybenzoyl)oxyacetic acid；2-(3,4,5-trihydroxybenzoyl)oxyacetic acid
• CAS: 50888-94-3
• 化学式: C₉H₈O₇
• 分子量: 228.158
• InChiKey: KAMUQJYKBDAMKC-UHFFFAOYSA-N

物化性质

• 沸点：
  625.3±55.0 °C(Predicted)
• 密度：
  1.705±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  没食子酸 、 氯乙酸乙酯 在 sodium hydroxide 作用下， 生成 galloyloxy-acetic acid
  参考文献：
  名称：

  Christiansen, Journal of the American Chemical Society, 1926, vol. 48, p. 1364

  摘要：

  DOI：

文献信息

• ALKOXYPHENYL DERIVATIVE, NUCLEOSIDE PROTECTOR, NUCLEOTIDE PROTECTOR, METHOD FOR PRODUCING OLIGONUCLEOTIDE, AND METHOD FOR REMOVING SUBSTITUENT
  申请人：Fujimoto Chemicals Co. Ltd.

  公开号：EP3825300A1

  公开（公告）日：2021-05-26

  The present invention relates to an alkoxyphenyl derivative capable of synthesizing an oligonucleotide by a quicker liquid phase synthesis method than in the prior art, a protected nucleoside and a protected nucleotide to which the alkoxyphenyl derivative is bonded, a method for producing an oligonucleotide using the same, and a method for selectively removing the alkoxyphenyl derivative moiety and the like. A compound represented by the general formula (1) or a derivative thereof: (In the formula, R each independently represents an optionally substituted alkyl group having 10 to 40 carbons. m represents an integer between 1 and 5. When m is 2 or more, a plurality of ROs may be the same or different. X represents O, S, NH, or NRN. n represents an integer from 1 to 4. RN represents an optionally substituted alkyl group having 1 to 6 carbons.)

  本发明涉及一种能以比现有技术更快的液相合成方法合成寡核苷酸的烷氧基苯基衍生物、与该烷氧基苯基衍生物键合的受保护核苷和受保护核苷酸、用其生产寡核苷酸的方法以及选择性去除烷氧基苯基衍生物分子的方法等。 通式（1）代表的化合物或其衍生物： 式中 R各自独立地代表具有 10 至 40 个碳原子的任选取代的烷基。 m 代表 1 至 5 之间的整数。当 m 为 2 或 2 以上时，多个 RO 可以相同或不同。 X 代表 O、S、NH 或 NRN。 n 代表 1 至 4 之间的整数。 RN 代表具有 1 至 6 个碳原子的任选取代的烷基）。
• Oral delivery of GLP-1 peptide analogs
  申请人：MEDIMMUNE LIMITED

  公开号：US11173124B2

  公开（公告）日：2021-11-16

  The present invention provides formulations for oral administration of GLP-1 peptide analogs, methods of making such formulations, and methods of treatment using such formulations.

  本发明提供了口服 GLP-1 肽类似物的制剂、制作这种制剂的方法以及使用这种制剂进行治疗的方法。
• ORAL DELIVERY OF GLP-1 PEPTIDE ANALOGS
  申请人：MEDIMMUNE LIMITED

  公开号：US20200323782A1

  公开（公告）日：2020-10-15

  The present invention provides formulations for oral administration of GLP-1 peptide analogs, methods of making such formulations, and methods of treatment using such formulations.
• ALKOXYPHENYL DERIVATIVES, PROTECTED NUCLEOSIDES AND PROTECTED NUCLEOTIDES, METHOD FOR PRODUCING OLIGONUCLEOTIDES, AND METHOD FOR REMOVING SUBSTITUENTS
  申请人：FUJIMOTO CHEMICALS CO., LTD.

  公开号：US20210317159A1

  公开（公告）日：2021-10-14

  The present invention relates to an alkoxyphenyl derivative capable of synthesizing an oligonucleotide by a quicker liquid phase synthesis method than in the prior art, a protected nucleoside and a protected nucleotide to which the alkoxyphenyl derivative is bonded, a method for producing an oligonucleotide using the same, and a method for selectively removing the alkoxyphenyl derivative moiety and the like. A compound represented by the general formula (1) or a derivative thereof: (In the formula, R each independently represents an optionally substituted alkyl group having 10 to 40 carbons. m represents an integer between 1 and 5. When m is 2 or more, a plurality of ROs may be the same or different. X represents O, S, NH, or NR N . n represents an integer from 1 to 4. R N represents an optionally substituted alkyl group having 1 to 6 carbons.)
• US3946749A
  申请人：——

  公开号：US3946749A

  公开（公告）日：1976-03-30