申请人:Laboratorios Ojer Pharma S.L.
公开号:EP2742932A1
公开(公告)日:2014-06-18
The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycol in an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1.
The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament.
Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailablity of the active ingredient, without toxic adverse effects.
本发明提供了一种凝胶组合物,该凝胶组合物包含:聚卡波非,用量为 1 至 5%(按重量计);聚乙烯基pirrolidone,用量为 4 至 8%(按重量计);甘油,用量为 1 至 10%(按重量计);以及丙二醇,用量为 20 至 40%(按重量计);其中:聚乙烯基吡咯烷酮与聚卡波非之间的重量比为 1:1 至 4:1, 甘油与聚卡波非之间的重量比为 0.5:1至2:1,丙二醇:聚卡波非的重量比为8:1至20:1。
本发明还提供了包含此类凝胶组合物的透明组合物及其制备工艺和用作药物的方法。
由于采用了特定的辅料、重量百分比和重量比来形成组合,所得到的组合物具有很高的生物粘附性和活性成分的生物利用率,而且不会产生毒性不良反应。