6-(N'-benzoyl-thioureido)-hexanoic acid | 108875-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(N'-benzoyl-thioureido)-hexanoic acid
• 英文别名: 6-(N'-Benzoyl-thioureido)-hexansaeure；6-{[(Phenylcarbonyl)carbamothioyl]amino}hexanoic acid；6-(benzoylcarbamothioylamino)hexanoic acid
• CAS: 108875-83-8
• 化学式: C₁₄H₁₈N₂O₃S
• 分子量: 294.375
• InChiKey: UCFIHZUZQGZUDV-UHFFFAOYSA-N

物化性质

• 熔点：
  127.5-128 °C
• 密度：
  1.240±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N'-苯甲酰基-N,N-二乙基硫脲 、 6-氨基己酸 在 potassium fluoride on basic alumina 作用下， 以 丙酮 为溶剂， 反应 0.05h， 以90%的产率得到6-(N'-benzoyl-thioureido)-hexanoic acid
  参考文献：
  名称：

  Synthesis of 1-benzoyl-3-alkylthioureas by transamidation under microwave in dry media

  摘要：

  1-Benzoyl-3,3-diethylthiourea was transamidated with several amines to the corresponding 1-benzoyl-3-alkylthioureas in open vessels under microwave irradiation using a domestic oven. The syntheses were performed in solvent-free conditions on potassium fluoride impregnated alumina. Yields were dramatically improved in comparison with classical heating under the same conditions. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00047-2

文献信息

• [EN] ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES<br/>[FR] HYDROXAMATES CONNECTES A L'ACYLUREE ET A LA SULFONYLUREE
  申请人：S BIO PTE LTD

  公开号：WO2005040101A1

  公开（公告）日：2005-05-06

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.

  本发明涉及羟肟酸酯化合物，这些化合物是组蛋白去乙酰化酶的抑制剂。更具体地，本发明涉及含有酰脲/磺酰脲的化合物及其制备方法。这些化合物可能作为治疗增殖性疾病以及涉及、与组蛋白去乙酰化酶活性有关的其他疾病的药物而有用。
• Acylurea Connected And Sulfonylurea Connected Hydroxamates
  申请人：Lim Ze-Yi

  公开号：US20080070954A1

  公开（公告）日：2008-03-20

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.

  本发明涉及羟酰胺化合物，其为组蛋白去乙酰化酶的抑制剂。更具体地说，本发明涉及含有酰基脲/磺酰基脲的化合物及其制备方法。这些化合物可能作为药物用于治疗增殖性疾病以及其他涉及或与具有组蛋白去乙酰化酶活性的酶相关的疾病。
• Rapid anxiety assessment in medical patients: Evidence for the validity of verbal anxiety ratings
  作者：Eric G. Benotsch、Susan K. Lutgendorf、David Watson、Lauri J. Fick、Elvira V. Lang

  DOI：10.1007/bf02895114

  日期：2000.9

  Rapid assessment of patient anxiety is necessary to insure quality care. A number of self-report measures provide valid and reliable measures of anxiety These measures can be time-consuming to complete, however and may be burdensome to medical patients who are in pain or acute anxiety states. Many medical procedures are performed in conditions in which written measures are cumbersome (e.g, patient in supine position), and scoring and interpretation of written measures in a busy clinical setting may be difficult for medical personnel. The present study provides validity data for a verbally administered (0-10) anxiety rating. One hundred and ninety-eight adult interventional radiology patients completed standard measures assessing state anxiety, trait Negative and Positive Affect and the dimensions of the five-factor model of personality. Verbal anxiety rating was highly correlated with Spielberger's State Anxiety Inventory, showed moderate correlations to the related constructs of neuroticism and trait Negative Affect, and was largely unrelated to theoretically distinct constructs. Verbal anxiety ratings made prior to the invasive procedure also predicted pain and anxiety during the procedure. The verbal anxiety rating also demonstrated sensitivity to changes in anxiety that occurred as a result of changes in situation. Findings support the convergent and discriminant validity of verbal anxiety ratings.
• EP1685094A4
  申请人：——

  公开号：EP1685094A4

  公开（公告）日：2007-08-22
• ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES
  申请人：S*Bio Pte Ltd

  公开号：EP1685094A1

  公开（公告）日：2006-08-02