ethyl 4,5-diphenyl-1H-pyrazole-1-acetate | 120982-78-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 4,5-diphenyl-1H-pyrazole-1-acetate
• 英文别名: 4,5-Diphenyl-1-(ethoxycarbonylmethyl)-pyrazole；ethyl 2-(4,5-diphenylpyrazol-1-yl)acetate
• CAS: 120982-78-7
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: USLGFBHQKZHFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 4,5-diphenyl-1H-pyrazole-1-acetate 生成 N-[3-(dimethylamino)propyl]-2-(4,5-diphenylpyrazol-1-yl)acetamide;hydrate;hydrochloride
  参考文献：
  名称：

  BAILEY, DENIS M.;POWLES, RONALD G.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-oxo-2-phenylethyl)benzaldehyde 、 肼基乙酸乙酯 以53的产率得到ethyl 4,5-diphenyl-1H-pyrazole-1-acetate
  参考文献：
  名称：

  1H-pyrazole-1-alkanamines antiarrhythmic compositions and use

  摘要：

  用于治疗哺乳动物心律失常的N-[烷基氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-(支链)烷酰胺和吡唑-1-烷胺，通过将吡唑-1-乙酸的较低烷基酯与适当的二胺反应后还原或通过将较低烷基吡唑-1-乙酸酯的阴离子与烷基化试剂反应后，用适当的胺取代酯来制备。

  公开号：

  US04916150A1

文献信息

• N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic
  申请人：Sterling Drug Inc.

  公开号：US04898880A1

  公开（公告）日：1990-02-06

  N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.

  N-[(杂环)烷基]-3,4（或4,5）-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，用于治疗哺乳动物的心律失常，通过将吡唑-1-乙酸或丙酸的低烷基酯与适当的（杂环烷基）胺反应或将吡唑-1-乙酸或丙酸与适当的（杂环烷基）胺反应来制备。
• 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use
  申请人：Sterling Drug, Inc.

  公开号：US04870095A1

  公开（公告）日：1989-09-26

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，用于治疗哺乳动物心律失常，通过将吡唑-1-乙酸或丙酸的较低烷基酯与适当的二胺反应制备，或通过将吡唑-1-乙酸或丙酸的较低烷基酯与.ω.-氨基烷醇反应，随后激活醇并被适当胺置换而制备。
• 1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents,
  申请人：Sterling Drug Inc.

  公开号：US04988725A1

  公开（公告）日：1991-01-29

  N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

  N-[(烷基氨基)烷基]-3,4(或4,5)-二芳基-1H-吡唑-1-(支链)烷酰胺和吡唑-1-烷基胺可用于治疗哺乳动物的心律失常，其制备方法为：将吡唑-1-乙酸的较低烷基酯与适当的二胺反应，然后还原，或将较低烷基吡唑-1-乙酸酯的阴离子与烷基化剂反应，然后通过适当的胺置换酯基。
• 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents
  申请人：STERLING DRUG INC.

  公开号：EP0299407A1

  公开（公告）日：1989-01-18

  N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-­1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester or pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an ω-­aminoalkanol, followed by activation of the alcohol and displacement of an appropriate amine.

  N-[(二取代氨基)烷基]-3,4(或 4,5)-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺，可用于治疗哺乳动物的心律失常、其制备方法是将吡唑-1-乙酸或丙酸的低级烷基酯与适当的二胺反应，或将吡唑-1-乙酸或丙酸的低级烷基酯与ω-氨基醇反应，然后使醇活化并置换适当的胺。
• Azole-1-alkanamides as antiarrhytmic agents and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0388690A1

  公开（公告）日：1990-09-26

  N-[(heterocycle)alkyl]3,4-(or 4,5)-diaryl-1H-­pyrazole-1-acetamides and pyrazole-1-propanamides or acid-addition salt thereof wherein R¹ is hydrogen or lower-alkyl; R² and R³ are independently hydrogen, hydroxy, lower-alkyl, lower-alkoxy, lower-alkylamino, lower-alkylamido, lower-alkylsulfonamido, nitro, amino, cyano, or halo; R⁴ is hydrogen or hydroxy; m is one or two; p is one, two, or three; and A is a five-or six membered heterocycle containing carbon, hydrogen and nitrogen and attached to (CH₂)p at a carbon, or A is a five-or six-membered heterocycle, substituted with a lower-alkyl group, containing carbon, hydrogen and nitrogen and attached to (CH₂)p at a carbon, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.

  N-[（杂环）烷基]3,4-（或 4,5）-二芳基-1H-吡唑-1-乙酰胺和吡唑-1-丙酰胺 或其酸加成盐 其中R¹是氢或低级烷基；R²和R³独立地是氢、羟基、低级烷基、低级烷氧基、低级烷基氨基、低级烷基酰胺、低级烷基磺酰胺、硝基、氨基、氰基或卤素；R⁴是氢或羟基；m是1或2；p是1、2或3；且 A 是含碳、氢和氮并在一个碳上与 (CH₂)p 连接的五或六元杂环，或 A 是被低级烷基取代的含碳、氢和氮并在一个碳上与 (CH₂)p 连接的五或六元杂环、通过将吡唑-1-乙酸或丙酸的低级烷基酯与适当的（杂环-烷基）胺反应，或通过将吡唑-1-乙酸或丙酸与适当的（杂环-烷基）胺反应，制备出有助于治疗哺乳动物心律失常的吡唑-1-乙酸或丙酸低级烷基酯。