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5-(4-氟苯基)吡嗪-2-羧酸 | 652979-82-3

中文名称
5-(4-氟苯基)吡嗪-2-羧酸
中文别名
——
英文名称
5-(4-fluorophenyl)-2-pyrazinecarboxylic acid
英文别名
5-(4-Fluorophenyl)pyrazine-2-carboxylic acid
5-(4-氟苯基)吡嗪-2-羧酸化学式
CAS
652979-82-3
化学式
C11H7FN2O2
mdl
——
分子量
218.187
InChiKey
UDUYQYBNZRZQIZ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.4
  • 重原子数:
    16
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    63.1
  • 氢给体数:
    1
  • 氢受体数:
    5

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    5-(4-氟苯基)吡嗪-2-羧酸 、 2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-amine 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下, 以 N,N-二甲基甲酰胺 为溶剂, 反应 16.0h, 生成 N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-(4-fluorophenyl)-2-pyrazinecarboxamide
    参考文献:
    名称:
    Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists
    摘要:
    A series of imidazo[1,2-a] pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a] pyridine provided compounds with a significant improvement in MCH1R affinity. Representative compounds in this series exhibited good potency and brain exposure in rats. (C) 2009 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.bmcl.2009.06.101
  • 作为产物:
    参考文献:
    名称:
    EP1657242
    摘要:
    公开号:
点击查看最新优质反应信息

文献信息

  • Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient
    申请人:Moriya Minoru
    公开号:US20050222161A1
    公开(公告)日:2005-10-06
    This invention relates to a benzimidazole derivative of the general formula [I] [wherein B 1 , B 2 , and B 3 represent hydrogen atom or lower alkyl; R 1 and R 2 are same or different and represent lower alkyl, etc.; R 3 and R 4 represent hydrogen atom, etc.; W represents a 3 to 8-membered aromatic or alphatic heterocycle, etc.; and Ar represents a substituted or unsubstituted aromatic heterocycle, etc.] This compound functions as an antagonist to melanin-concentrating hormone receptor and is useful as a drug for central diseases, circulatory diseases and metabolic diseases.
    本发明涉及一种苯并咪唑衍生物,其一般式为[I] [其中B1,B2和B3代表氢原子或低碳基; R1和R2相同或不同,代表低碳基等; R3和R4代表氢原子等; W代表3至8个成员的芳香或脂肪族杂环等; Ar代表取代或未取代的芳香族杂环等] 该化合物作为黑色素浓缩激素受体的拮抗剂,并可用作中枢疾病、循环系统疾病和代谢性疾病的药物。
  • Imidazopyridine Derivatives
    申请人:Kishino Hiroyuki
    公开号:US20080200494A1
    公开(公告)日:2008-08-21
    The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R 1 and R 2 may be the same or different and stand for C 1-6 alkyl or the like, R 3 and R 4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
    该发明提供了由通式[I]表示的咪唑吡啶衍生物 [其中R1和R2可能相同或不同,且代表C1-6烷基或类似物,R3和R4代表氢原子,甲基基团或类似物,W代表单环或双环的3-8元芳香或脂肪杂环或类似物,Ar代表可选择取代的芳香杂环或类似物]。这些化合物作为黑色素浓集激素受体拮抗剂,可用于治疗中枢神经系统疾病、心血管系统疾病和代谢性疾病的药物。
  • Imidazopyridine derivatives
    申请人:Banyu Pharmaceuticals, Co., Ltd.
    公开号:US07504412B2
    公开(公告)日:2009-03-17
    The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
    本发明提供了由通式[I]表示的咪唑吡啶衍生物 [其中R1和R2可以相同或不同,代表C1-6烷基或类似物,R3和R4代表氢原子,甲基基团或类似物,W代表单环或双环3-8成员的芳香或脂肪族杂环或类似物,Ar代表可选取代的芳香杂环或类似物]。这些化合物作为黑素浓聚激素受体拮抗剂,并且可用于治疗中枢神经系统疾病、心血管系统疾病和代谢性疾病的药物。
  • NOVEL MCH RECEPTOR ANTAGONISTS
    申请人:Beck James Peter
    公开号:US20090170913A1
    公开(公告)日:2009-07-02
    The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar 1 , L 1 , R 1 , q, X, R 2 , R 3 , R 4 , and R 5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
    本发明涉及一种公式(I)的黑色素浓集激素拮抗剂化合物;其中Ar1,L1,R1,q,X,R2,R3,R4和R5如定义,或其药学上可接受的盐,溶剂合物或对映体,用于治疗,预防或改善与肥胖和相关疾病相关的症状。
  • IMIDAZOPYRIDINE DERIVATIVES
    申请人:BANYU PHARMACEUTICAL CO., LTD.
    公开号:EP1657242A1
    公开(公告)日:2006-05-17
    The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
    本发明提供由通式[I]代表的咪唑吡啶衍生物[其中 R1 和 R2 可以相同或不同,代表 C1-6 烷基或类似物,R3 和 R4 代表氢原子、甲基或类似物,W 代表单环或双环 3 至 8 元芳香族或脂肪族杂环或类似物,Ar 代表任选取代的芳香族杂环或类似物]。这些化合物具有黑色素浓缩激素受体拮抗剂的作用,可作为治疗中枢神经系统疾病、心血管系统疾病和代谢紊乱的药物。
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