[(2S)-1-[4-(phenoxymethyl)phenyl]sulfonylpyrrolidin-2-yl]-diphenylmethanol | 1037067-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2S)-1-[4-(phenoxymethyl)phenyl]sulfonylpyrrolidin-2-yl]-diphenylmethanol
• CAS: 1037067-62-1
• 化学式: C₃₀H₂₉NO₄S
• 分子量: 499.631
• InChiKey: QZUFZQRMEXNOIF-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  [(S)-1-(4-Bromomethyl-benzenesulfonyl)-pyrrolidin-2-yl]-diphenyl-methanol 、 苯酚 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以96%的产率得到[(2S)-1-[4-(phenoxymethyl)phenyl]sulfonylpyrrolidin-2-yl]-diphenylmethanol
  参考文献：
  名称：

  Asymmetric borane reduction of prochiral ketones catalyzed by C3-symmetric sulfonamide

  摘要：

  A novel, recoverable, C(3)-symmetric sulfonamide L-1 has been developed for the asymmetric borane reduction of prochiral ketones in refluxing THF. The optically active secondary alcohols were obtained in excellent enantiometric excesses (up to 97% ee) and good yields. The C(3)-symmetric sulfonamide L-1 can be easily recovered and reused four times without any significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.012

文献信息

• Asymmetric borane reduction of prochiral ketones catalyzed by C3-symmetric sulfonamide
  作者：Gao-Qiang Li、Ze-Yi Yan、Yan-Ning Niu、Lu-Yong Wu、Hai-Long Wei、Yong-Min Liang

  DOI：10.1016/j.tetasy.2008.03.012

  日期：2008.4

  A novel, recoverable, C(3)-symmetric sulfonamide L-1 has been developed for the asymmetric borane reduction of prochiral ketones in refluxing THF. The optically active secondary alcohols were obtained in excellent enantiometric excesses (up to 97% ee) and good yields. The C(3)-symmetric sulfonamide L-1 can be easily recovered and reused four times without any significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.