3-(4-chlorophenyl)-2,6-piperidinedione | 459132-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(4-chlorophenyl)-2,6-piperidinedione
• 英文别名: 3-(4-chlorophenyl)piperidine-2,6-dione；para-chlorophenyl-glutaric acid imide
• CAS: 459132-81-1
• 化学式: C₁₁H₁₀ClNO₂
• 分子量: 223.659
• InChiKey: FHCOZQYKEWVNCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 3-(4-chlorophenyl)-2,6-piperidinedione 、 磺胺甲恶唑 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 0.5h， 生成 4-(((3-(4-chlorophenyl)-2,6-dioxopiperidin-1-yl)methyl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  参考文献：
  名称：

  SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES

  摘要：

  A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing H-1 NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.

  DOI：

  10.4067/s0717-97072010000300001
• 作为产物：
  描述：

  对氯苯乙酸 在 四乙酰基二硼氧烷 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 尿素 作用下， 以 二乙二醇二甲醚 、 甲苯 为溶剂， 反应 66.0h， 生成 3-(4-chlorophenyl)-2,6-piperidinedione
  参考文献：
  名称：

  硼催化供体-受体羧酸对的迈克尔反应可直接合成 1,5-二羧酸

  摘要：

  开发了使用成对羧酸的硼催化迈克尔反应。该反应通过硼催化剂对两种底物的双重活化而发生，这促进了供体羧酸形成硼烯醇化物，同时活化作为受体的α,β-不饱和羧酸。 α-芳基和α-烯基羧酸可用作供体。通过直接使用药物作为供体羧酸证明了该反应的多功能性和实用性。

  DOI：

  10.1021/acs.orglett.4c01542

文献信息

• GLUTARIMIDES 3-ARYL-3-CARBOXYALKYL SUBSTITUES, LEUR PREPARATION PAR CYCLISATION D'ACIDES DICARBOXYLIQUES DE LA 4-ARYL-4-CYANOHEPTANE ET LEUR UTILISATION POUR LA PREPARATION DE 3-ARYL-3-HYDROXYALKYLPIPERIDINES
  申请人：SANOFI-SYNTHELABO

  公开号：EP0888304B1

  公开（公告）日：2001-10-04
• SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
  作者：ANJU DAS MANIKPURI、SHEELA JOSHI、PADMAKAR V KHADIKAR

  DOI：10.4067/s0717-97072010000300001

  日期：——

  A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing H-1 NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.
• 10.1021/acs.orglett.4c01542
  作者：Yoshida, Yukiho、Sawamura, Masaya、Shimizu, Yohei

  DOI：10.1021/acs.orglett.4c01542

  日期：——

  A boron-catalyzed Michael reaction using pairs of carboxylic acids was developed. The reaction occurs through dual activation of the two substrates by a boron catalyst, which facilitates boron enolate formation from the donor carboxylic acid with simultaneous activation of the α,β-unsaturated carboxylic acid as the acceptor. α-Aryl and α-alkenyl carboxylic acids were applicable as donors. The versatility

  开发了使用成对羧酸的硼催化迈克尔反应。该反应通过硼催化剂对两种底物的双重活化而发生，这促进了供体羧酸形成硼烯醇化物，同时活化作为受体的α,β-不饱和羧酸。 α-芳基和α-烯基羧酸可用作供体。通过直接使用药物作为供体羧酸证明了该反应的多功能性和实用性。