2-(Dihexadecylamino)-2-(hydroxymethyl)propane-1,3-diol | 1016895-69-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(Dihexadecylamino)-2-(hydroxymethyl)propane-1,3-diol
• CAS: 1016895-69-4
• 化学式: C₃₆H₇₅NO₃
• 分子量: 569.996
• InChiKey: RFTSDBCYCPWMPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.6
• 重原子数：
  40
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(Dihexadecylamino)-2-(hydroxymethyl)propane-1,3-diol 、 碘甲烷 生成
  参考文献：
  名称：

  Covalent Grafting of Common Trihydroxymethylaminomethane in the Headgroup Region Imparts High Serum Compatibility and Mouse Lung Transfection Property to Cationic Amphiphile

  摘要：

  Clinical success of cationic transfection lipids in nonviral gene therapy continues to remain critically dependent on the use of serum compatible cationic amphiphiles efficient in delivering genes into our body cells. To this end, we demonstrate that covalent grafting of simple Tris-base component of the widely used biological Tris buffer in the headgroup region is capable of imparting high serum compatibility and intravenous mouse lung transfection properties to cationic amphiphile.

  DOI：

  10.1021/jm070879u
• 作为产物：
  描述：

  三羟甲基氨基甲烷 、 溴代十六烷 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 16.0h， 以31%的产率得到2-(Dihexadecylamino)-2-(hydroxymethyl)propane-1,3-diol
  参考文献：
  名称：

  Covalent Grafting of Common Trihydroxymethylaminomethane in the Headgroup Region Imparts High Serum Compatibility and Mouse Lung Transfection Property to Cationic Amphiphile

  摘要：

  Clinical success of cationic transfection lipids in nonviral gene therapy continues to remain critically dependent on the use of serum compatible cationic amphiphiles efficient in delivering genes into our body cells. To this end, we demonstrate that covalent grafting of simple Tris-base component of the widely used biological Tris buffer in the headgroup region is capable of imparting high serum compatibility and intravenous mouse lung transfection properties to cationic amphiphile.

  DOI：

  10.1021/jm070879u

文献信息

• Covalent Grafting of Common Trihydroxymethylaminomethane in the Headgroup Region Imparts High Serum Compatibility and Mouse Lung Transfection Property to Cationic Amphiphile
  作者：Koushik Mukherjee、Jayanta Bhattacharyya、Joyeeta Sen、Ramakrishna Sistla、Arabinda Chaudhuri

  DOI：10.1021/jm070879u

  日期：2008.3.1

  Clinical success of cationic transfection lipids in nonviral gene therapy continues to remain critically dependent on the use of serum compatible cationic amphiphiles efficient in delivering genes into our body cells. To this end, we demonstrate that covalent grafting of simple Tris-base component of the widely used biological Tris buffer in the headgroup region is capable of imparting high serum compatibility and intravenous mouse lung transfection properties to cationic amphiphile.