3-allyl 1-tert-butyl (R)-2-oxo-5-vinylpyrrolidine-1,3-dicarboxylate | 1215309-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-allyl 1-tert-butyl (R)-2-oxo-5-vinylpyrrolidine-1,3-dicarboxylate
• 英文别名: 1-O-tert-butyl 3-O-prop-2-enyl (5R)-5-ethenyl-2-oxopyrrolidine-1,3-dicarboxylate
• CAS: 1215309-47-9
• 化学式: C₁₅H₂₁NO₅
• 分子量: 295.335
• InChiKey: SVZNWFIOLBOQTE-VUWPPUDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-allyl 1-tert-butyl (R)-2-oxo-5-vinylpyrrolidine-1,3-dicarboxylate 在 吗啉 、 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到tert-butyl (R)-2-oxo-5-vinylpyrrolidine-1-carboxylate
  参考文献：
  名称：

  Enantioselective synthesis of condensed and transannular ring skeletons containing pyrrolidine moiety

  摘要：

  A new approach toward condensed and transannular ring structures Containing pyrrolidine unit has been developed, based on diastereoselective nucleophilic addition of lithium of alpha-diazoacetoacetate to chiral N-sulfillyl imine and ring-closing metathesis (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.013
• 作为产物：
  描述：

  allyl (R)-5-(tert-butoxycarbonylamino)-2-diazo-3-oxohept-6-enoate 以 苯 为溶剂， 以60%的产率得到3-allyl 1-tert-butyl (R)-2-oxo-5-vinylpyrrolidine-1,3-dicarboxylate
  参考文献：
  名称：

  Enantioselective synthesis of condensed and transannular ring skeletons containing pyrrolidine moiety

  摘要：

  A new approach toward condensed and transannular ring structures Containing pyrrolidine unit has been developed, based on diastereoselective nucleophilic addition of lithium of alpha-diazoacetoacetate to chiral N-sulfillyl imine and ring-closing metathesis (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.013

文献信息

• Enantioselective synthesis of condensed and transannular ring skeletons containing pyrrolidine moiety
  作者：Fanyang Mo、Fei Li、Di Qiu、Jianbo Wang

  DOI：10.1016/j.tet.2009.12.013

  日期：2010.2

  A new approach toward condensed and transannular ring structures Containing pyrrolidine unit has been developed, based on diastereoselective nucleophilic addition of lithium of alpha-diazoacetoacetate to chiral N-sulfillyl imine and ring-closing metathesis (C) 2009 Elsevier Ltd All rights reserved