3-(thiophen-2-yl)piperidine | 862718-69-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(thiophen-2-yl)piperidine
• 英文别名: 3-thiophen-2-ylpiperidine
• CAS: 862718-69-2
• 化学式: C₉H₁₃NS
• 分子量: 167.275
• InChiKey: ZRTROWVOYFUWEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(thiophen-2-yl)piperidine 、 3'-氯-4-氟苯丙酮 在 potassium carbonate 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以47%的产率得到1-(4-fluorophenyl)-3-(3-thiophen-2-ylpiperidin-1-yl)propan-1-one
  参考文献：
  名称：

  Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

  摘要：

  A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D-4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.060
• 作为产物：
  描述：

  N-叔丁氧羰基-3-哌啶酮 在 palladium on activated charcoal 、 四(三苯基膦)钯 氢气 、 三氟乙酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 为溶剂， 反应 2.25h， 生成 3-(thiophen-2-yl)piperidine
  参考文献：
  名称：

  Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

  摘要：

  A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D-4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.060

文献信息

• [EN] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES ET 3-CYANO-1,7-NAPHTHYRIDINES UTILISEES COMME INHIBITEURS DE PROTEINEKINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001072711A1

  公开（公告）日：2001-10-04

  Compounds of Formula (I), having the structure or a pharmaceutically salt thereof are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

  具有结构式（I）或其药物盐的化合物在抗肿瘤药物和治疗骨质疏松症和多囊肾病方面是有用的。
• 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1268431A1

  公开（公告）日：2003-01-02
• Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists
  作者：Xueqing Wang、Pramila A. Bhatia、Jerome F. Daanen、Steve P. Latsaw、Jeffrey Rohde、Teodozyi Kolasa、Ahmed A. Hakeem、Mark A. Matulenko、Masaki Nakane、Marie E. Uchic、Loan N. Miller、Renjie Chang、Robert B. Moreland、Jorge D. Brioni、Andrew O. Stewart

  DOI：10.1016/j.bmc.2005.04.060

  日期：2005.8

  A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D-4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. (c) 2005 Elsevier Ltd. All rights reserved.