3-(3'-(2''-phenylphenoxy)-2'-hydroxypropyl)-5,5-dimethylimidazolidine-2,4-dione | 842961-40-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3'-(2''-phenylphenoxy)-2'-hydroxypropyl)-5,5-dimethylimidazolidine-2,4-dione
• 英文别名: 3-[3-(Biphenyl-2-yloxy)-2-hydroxy-propyl]-5,5-dimethyl-imidazolidine-2,4-dione；3-[2-hydroxy-3-(2-phenylphenoxy)propyl]-5,5-dimethylimidazolidine-2,4-dione
• CAS: 842961-40-4
• 化学式: C₂₀H₂₂N₂O₄
• 分子量: 354.406
• InChiKey: XUTQNNVXBRNGBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻苯基苯酚 在 吡啶 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 16.0h， 生成 3-(3'-(2''-phenylphenoxy)-2'-hydroxypropyl)-5,5-dimethylimidazolidine-2,4-dione
  参考文献：
  名称：

  Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

  摘要：

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.099

文献信息

• Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
  作者：Elizabeth Fullam、Areej Abuhammad、David L. Wilson、Matthew C. Anderton、Steve G. Davies、Angela J. Russell、Edith Sim

  DOI：10.1016/j.bmcl.2010.12.099

  日期：2011.2

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.