(S)-2-(2,3-Epoxypropoxy)[1,1'-biphenyl] | 176760-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(2,3-Epoxypropoxy)[1,1'-biphenyl]
• 英文别名: (2S)-2-[(2-phenylphenoxy)methyl]oxirane
• CAS: 176760-82-0
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: DNVXWIINBUTFEP-ZDUSSCGKSA-N

物化性质

• 沸点：
  371.0±0.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-Dimethoxyphenaethylamin(TMS) 、 (S)-2-(2,3-Epoxypropoxy)[1,1'-biphenyl] 以 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-1-(Biphenyl-2-yloxy)-3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-propan-2-ol
  参考文献：
  名称：

  The Application of High-Throughput Synthesis And Purification To The Preparation Of Ethanolamines

  摘要：

  A 48 compound library of structurally diverse ethanolamines was prepared using a parallel synthesis approach. The synthetic paradigm employed a solution phase epoxide-opening reaction followed by rapid purification by ion exchange chromatography to yield products with near-analytical purity. An array of epoxides and primary amines, arranged in an 8x6 matrix, were reacted in the presence of an in situ silylating agent to form 48 individual compounds with an average yield of 75% and an average purity of 92.3%. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01421-4
• 作为产物：
  描述：

  邻苯基苯酚 生成 (S)-2-(2,3-Epoxypropoxy)[1,1'-biphenyl]
  参考文献：
  名称：

  Benzo 1,3 dioxole derivatives

  摘要：

  公式为##STR1##的化合物及其药用可接受盐，其中A是苯基、萘基或二氢萘基或四氢萘基，其芳环上可选地被一个到三个取代基独立地选自卤素、氰基、三氟甲基、硝基、烷氧基、烷基磺酰基、烷基、环烷基、芳基或氢键供体；B是键或氧原子，R1至R4如定义于此。这些化合物是β3肾上腺素能受体激动剂，因此在糖尿病、肥胖症和胃肠道疾病的治疗中非常有用。

  公开号：

  US05488064A1

文献信息

• Aryloxypropanolamine beta 3 adrenergic agonists
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0714883A1

  公开（公告）日：1996-06-05

  Compounds of the formula I and pharmaceutically acceptable salts thereof wherein:    R1 to R9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.

  式 I 的化合物 及其药学上可接受的盐 其中 R1 至 R9 如本文所定义，m 为整数 0 或 1。这些化合物是β3肾上腺素能受体激动剂，因此可用于治疗糖尿病、肥胖症、胃肠道疾病和贲门失弛缓症等。
• US5541204A
  申请人：——

  公开号：US5541204A

  公开（公告）日：1996-07-30
• US5488064A
  申请人：——

  公开号：US5488064A

  公开（公告）日：1996-01-30
• The Application of High-Throughput Synthesis And Purification To The Preparation Of Ethanolamines
  作者：Anthony J. Shuker、Miles G. Siegel、Donald P. Matthews、Leland O. Weigel

  DOI：10.1016/s0040-4039(97)01421-4

  日期：1997.9

  A 48 compound library of structurally diverse ethanolamines was prepared using a parallel synthesis approach. The synthetic paradigm employed a solution phase epoxide-opening reaction followed by rapid purification by ion exchange chromatography to yield products with near-analytical purity. An array of epoxides and primary amines, arranged in an 8x6 matrix, were reacted in the presence of an in situ silylating agent to form 48 individual compounds with an average yield of 75% and an average purity of 92.3%. (C) 1997 Elsevier Science Ltd.
• Benzo 1,3 dioxole derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05488064A1

  公开（公告）日：1996-01-30

  Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof where A is phenyl, naphthyl or dihydro- or tetrahydronaphthyl optionally substituted on the aromatic ring by one to three substituents independently selected from halogen, cyano, trifluoromethyl, nitro, alkoxy, alkylsulfonyl, alkyl, cycloalkyl, aryl or a hydrogen bond donor; B is a bond or an oxygen atom and R.sup.1 to R.sup.4 are as defined herein. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.

  公式为##STR1##的化合物及其药用可接受盐，其中A是苯基、萘基或二氢萘基或四氢萘基，其芳环上可选地被一个到三个取代基独立地选自卤素、氰基、三氟甲基、硝基、烷氧基、烷基磺酰基、烷基、环烷基、芳基或氢键供体；B是键或氧原子，R1至R4如定义于此。这些化合物是β3肾上腺素能受体激动剂，因此在糖尿病、肥胖症和胃肠道疾病的治疗中非常有用。