2,3,5-trichloro-6-hydroxy-benzyl alcohol | 4752-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5-trichloro-6-hydroxy-benzyl alcohol
• 英文别名: 2,3,5-Trichlor-6-hydroxy-benzylalkohol；3,4,6-Trichloro-2-(hydroxymethyl)phenol
• CAS: 4752-64-1
• 化学式: C₇H₅Cl₃O₂
• 分子量: 227.475
• InChiKey: ZRGPVGCJLRWSFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,5-trichloro-6-hydroxy-benzyl alcohol 、 2,2-二氯丙酸 生成 2,2-dichloro-propionic acid-(2,3,5-trichloro-6-hydroxy-benzyl ester)
  参考文献：
  名称：

  Polychlorosaligenin esters of 2, 2-dichloropropionic acid

  摘要：

  公开号：

  US02815367A1
• 作为产物：
  描述：

  聚合甲醛 、 2,4,5-三氯苯酚 在 sodium hydroxide 作用下， 生成 2,3,5-trichloro-6-hydroxy-benzyl alcohol
  参考文献：
  名称：

  Method for preparing substituted hydroxy benzyl alcohol

  摘要：

  公开号：

  US02631169A1

文献信息

• Arct,J. et al., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1967, vol. 15, # 6, p. 233 - 238
  作者：Arct,J. et al.

  DOI：——

  日期：——
• Preparation of asymmetrical bisphenols
  申请人：——

  公开号：US02733273A1

  公开（公告）日：1956-01-31
• Halogenated o, o' dihydroxy diphenyl methane alkyl ether
  申请人：GEN ANILINE &

  公开号：US02684386A1

  公开（公告）日：1954-07-20
• Antibacterial Use of Halogenated Salicylanilides
  申请人：ANTIBIOTX APS

  公开号：US20170258816A1

  公开（公告）日：2017-09-14

  The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus , in particular Staphylococcus aureus , and Streptococcus , in particular Streptococcus pyogenes . Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
• ANTIBACTERIAL USE OF HALOGENATED SALICYLANILIDES
  申请人：ANTIBIOTX APS

  公开号：US20170326160A1

  公开（公告）日：2017-11-16

  The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus , in particular Staphylococcus aureus , and Streptococcus , in particular Streptococcus pyogenes . Gram positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.