4-nitrophenyl 4-(pyren-1-yl)butanoate | 121618-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 4-nitrophenyl 4-(pyren-1-yl)butanoate
• 英文别名: 4-Nitrophenyl 4-(1-pyrenyl)butanoate；(4-Nitrophenyl) 4-pyren-1-ylbutanoate
• CAS: 121618-88-0
• 化学式: C₂₆H₁₉NO₄
• 分子量: 409.441
• InChiKey: PUBZTHXZURPXEB-UHFFFAOYSA-N

物化性质

• 沸点：
  632.6±48.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  1-芘丁酸	1-pyrenebutyric acid	3443-45-6	C20H16O2	288.346

反应信息

• 作为反应物：
  描述：

  4-nitrophenyl 4-(pyren-1-yl)butanoate 、 γ-环糊精 在 carbonate buffer solution 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成 2-O-4-<(1-Pyrenyl)butanoyl>-γ-cyclodextrin 、 3-O-4-<(1-Pyrenyl)butanoyl>-γ-cyclodextrin
  参考文献：
  名称：

  Association dimers, excimers, and inclusion complexes of pyrene-appended .gamma.-cyclodextrins

  摘要：

  DOI：

  10.1021/ja00198a061
• 作为产物：
  描述：

  对硝基苯酚 、 1-芘丁酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成 4-nitrophenyl 4-(pyren-1-yl)butanoate
  参考文献：
  名称：

  Association dimers, excimers, and inclusion complexes of pyrene-appended .gamma.-cyclodextrins

  摘要：

  DOI：

  10.1021/ja00198a061

文献信息

• Oligonucleotide-polyamide conjugates
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0972779A2

  公开（公告）日：2000-01-19

  Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

  式 X-L-Y 的寡核苷酸-聚酰胺共轭物，其中 X 是聚酰胺，Y 是寡核苷酸，L 是连接体，它与聚酰胺 X 的氨基末端和寡核苷酸 Y 的 3'磷酸基团形成共价键。可通过在固体支持基质上组装聚酰胺，加入合适的连接分子，然后合成寡核苷酸来合成共轭物。还介绍了用寡核苷酸-聚酰胺共轭物检测特定多核苷酸的方法。
• MOLECULAR MODULE
  申请人：The University of Tokyo

  公开号：EP2098538A1

  公开（公告）日：2009-09-09

  The present invention aims at providing a general-purpose experimental tool which specifically binds to a macromolecular substance that will be a receptor for a specific ligand such as drug, and is applicable throughout various processes to explore the nature of the macromolecular substance. In order to achieve this object, a molecular module has been developed which binds to a target compound and is used for purifying or labeling the target compound, wherein the molecular module has a rod-like spacer substance, an interacting substance that interacts with the target compound, a tag and a labeling substance, the interacting substance being positioned at one end of the rod-like spacer substance, and the tag and the labeling substance being positioned at the other end of the rod-like spacer substance.

  本发明的目的是提供一种通用的实验工具，它能专门与大分子物质结合，使其成为特定配体（如药物）的受体，并适用于探索大分子物质性质的各种过程。为了实现这一目标，我们开发了一种分子模块，它能与目标化合物结合，并用于纯化或标记目标化合物，其中分子模块具有杆状间隔物质、与目标化合物相互作用的相互作用物质、标签和标记物质，相互作用物质位于杆状间隔物质的一端，标签和标记物质位于杆状间隔物质的另一端。
• Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
  申请人：Baker F. Brenda

  公开号：US20050037370A1

  公开（公告）日：2005-02-17

  Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a modified base for binding to an adenine or guanine base in the opposite strand. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has a modified base for binding to an adenine or guanine base in the opposite strand.

  提供了包含第一和第二寡聚体的寡聚体组合物，其中第一寡聚体的至少一部分能够与第二寡聚体的至少一部分杂交，第一寡聚体的至少一部分与所选靶核酸互补并能够与所选靶核酸杂交，第一或第二寡聚体的至少一种具有修饰碱基，用于与相反链中的腺嘌呤或鸟嘌呤碱基结合。还提供了寡核苷酸/蛋白质组合物，该组合物包含与所选靶核酸互补并能与之杂交的寡聚体，以及至少一种包含 RNA 诱导沉默复合体（RISC）至少一部分的蛋白质，其中寡聚体具有与相反链中腺嘌呤或鸟嘌呤碱基结合的修饰碱基。
• OLIGONUCLEOTIDE-POLYAMIDE CONJUGATES
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0644890B1

  公开（公告）日：2001-12-05
• NUCLEOSIDE DERIVATIVES
  申请人：HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE

  公开号：EP0366685A1

  公开（公告）日：1990-05-09