5-(2-isopropylphenyl)-furan-2-carbaldehyde | 1094322-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-isopropylphenyl)-furan-2-carbaldehyde
• 英文别名: 5-(2-Propan-2-ylphenyl)furan-2-carbaldehyde
• CAS: 1094322-44-7
• 化学式: C₁₄H₁₄O₂
• 分子量: 214.264
• InChiKey: OPOPSADXBVPHPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(2-isopropylphenyl)-furan-2-carbaldehyde 、 肼甲酰亚胺酰胺一氯化氢 以 乙醇 为溶剂， 130.0 ℃ 、400.01 kPa 条件下， 反应 0.2h， 以95%的产率得到2-((5-(2-isopropylphenyl)furan-2-yl)methylene)hydrazinecarboximidamide hydrochloride
  参考文献：
  名称：

  Discovery of Selective Nonpeptidergic Neuropeptide FF2 Receptor Agonists

  摘要：

  We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3)are active in various pain models in vivo, whereas administration of it nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli.

  DOI：

  10.1021/jm9011998
• 作为产物：
  描述：

  糠醛 、 2-碘异丙基苯 在 四丁基溴化铵 、 potassium acetate 、 palladium dichloride 、 2-(二环己基膦基)联苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以55%的产率得到5-(2-isopropylphenyl)-furan-2-carbaldehyde
  参考文献：
  名称：

  Discovery of Selective Nonpeptidergic Neuropeptide FF2 Receptor Agonists

  摘要：

  We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3)are active in various pain models in vivo, whereas administration of it nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli.

  DOI：

  10.1021/jm9011998

文献信息

• Bright, Color-Tunable Fluorescent Dyes in the Vis/NIR Region: Establishment of New “Tailor-Made” Multicolor Fluorophores Based on Borondipyrromethene
  作者：Keitaro Umezawa、Akihiro Matsui、Yuki Nakamura、Daniel Citterio、Koji Suzuki

  DOI：10.1002/chem.200801906

  日期：2009.1.19

  reported. The KFL dyes cover a wide spectral range from the yellow (547 nm) to the near‐infrared (NIR, 738 nm) region, and their emission wavelength could be easily and subtly controlled based on simple molecular modifications only, without losing their optical properties. This “tailor‐made” synthetic strategy for tuning the emission wavelength enabled the creation of fourteen KFL dyes with well‐controlled

  据报道，一系列新的高性能荧光团称为Keio Fluors（KFL），其基于硼二吡咯亚甲基（BODIPY）。KFL染料涵盖了从黄色（547 nm）到近红外（NIR，738 nm）区域的宽光谱范围，并且仅基于简单的分子修饰就可以轻松，巧妙地控制其发射波长，而不会损失其光学特性。通过这种“量身定制”的合成策略来调节发射波长，可以创建十四种具有良好控制发射颜色（黄色，橙色，红色，远红色和NIR）的KFL染料。此外，这些KFL染料还保留了其出色的光学性能，例如比量子点更清晰的光谱带，高消光系数（140 000–316 000  M -1  cm -1）和高量子产率（0.56-0.98），而没有任何关键的溶剂极性依赖于其亮度降低。这些有利的特性使KFL染料有可能用作荧光标准染料的新候选者，以替代或补充现有的长波长荧光染料，例如花青，恶嗪，若丹明或其他BODIPY染料。
• Discovery of Selective Nonpeptidergic Neuropeptide FF2 Receptor Agonists
  作者：Gilles Gaubert、Fabio Bertozzi、Nicholas M. Kelly、Jan Pawlas、Audra L. Scully、Norman R. Nash、Luis R. Gardell、Jelveh Lameh、Roger Olsson

  DOI：10.1021/jm9011998

  日期：2009.11.12

  We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3)are active in various pain models in vivo, whereas administration of it nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli.