N-dansyldiglycine | 65251-19-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-dansyldiglycine
• 英文别名: N-[5-(Dimethylamino)naphthalene-1-sulfonyl]glycylglycine；2-[[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]acetyl]amino]acetic acid
• CAS: 65251-19-6
• 化学式: C₁₆H₁₉N₃O₅S
• 分子量: 365.41
• InChiKey: WVCXDDISXBUDDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-dansyldiglycine 、 copper(II) sulfate 以 aq. phosphate buffer 为溶剂， 生成
  参考文献：
  名称：

  A dual-responsive and highly sensitive fluorescent probe for Cu2+ and pH based on a dansyl derivative

  摘要：

  Herein, a dansyl-based fluorescent probe bearing a glycylglycine group (GG-Dns) is reported. The probe demonstrates suitable selectivity and sensitivity towards Cu2+ in aqueous media over a wide pH range (6-13) through a fluorescence "turn-off' mechanism. The determined detection limit is 0.29 mu M (Cu2+ concentration), and the association constant is 3.09 x 10(4) M-1, with 1:1 coordinate stoichiometric ratio. The probe displays an appropriate detection performance for Cu2+ in real drinking water samples, indicating the potential applicability of GG-Dns even in complex environments. Furthermore, in aqueous environments with pH below 6, GG-Dns is sensitive toward pH changes within a narrow range and with a fluorescence "on-off' function. The sensitive detection characteristics of Cu2+ can be ascribed to the coordination performance of GG moiety to Cu2+, whereas pH responsiveness is ascribed to the protonation of Dns moiety's dimethylamine group.

  DOI：

  10.1016/j.dyepig.2020.108513
• 作为产物：
  描述：

  Ethyl 2-[[2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]acetyl]amino]acetate 在 sodium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 生成 N-dansyldiglycine
  参考文献：
  名称：

  A dual-responsive and highly sensitive fluorescent probe for Cu2+ and pH based on a dansyl derivative

  摘要：

  Herein, a dansyl-based fluorescent probe bearing a glycylglycine group (GG-Dns) is reported. The probe demonstrates suitable selectivity and sensitivity towards Cu2+ in aqueous media over a wide pH range (6-13) through a fluorescence "turn-off' mechanism. The determined detection limit is 0.29 mu M (Cu2+ concentration), and the association constant is 3.09 x 10(4) M-1, with 1:1 coordinate stoichiometric ratio. The probe displays an appropriate detection performance for Cu2+ in real drinking water samples, indicating the potential applicability of GG-Dns even in complex environments. Furthermore, in aqueous environments with pH below 6, GG-Dns is sensitive toward pH changes within a narrow range and with a fluorescence "on-off' function. The sensitive detection characteristics of Cu2+ can be ascribed to the coordination performance of GG moiety to Cu2+, whereas pH responsiveness is ascribed to the protonation of Dns moiety's dimethylamine group.

  DOI：

  10.1016/j.dyepig.2020.108513

文献信息

• Initial Amino Acid:Codon Assignments and Strength of Codon:Anticodon Binding
  作者：Meng Su、Samuel J. Roberts、John D. Sutherland

  DOI：10.1021/jacs.4c03644

  日期：2024.5.8

  nucleophilic amino group and electrophilic ester carbonyl group. Reasoning that intrinsic codon:anticodon binding might have been a major contributor to bringing tRNA 3′-termini into proximity at an early stage of ribosomal peptide synthesis, we wondered if primordial amino acids might have been assigned to those codons that bind the corresponding anticodon loops most tightly. By measuring the binding of anticodon

  核糖体将 3'-氨酰基-tRNA 和 3'-肽基-tRNA 结合在一起，通过两种主要方式结合它们来实现肽基转移。首先，它们的反密码子环与 mRNA 结合，而 mRNA 本身锚定在核糖体亚基界面上，通过与小核糖体亚基解码中心的相互作用增强的连续反密码子：密码子配对。其次，它们的受体茎与肽基转移酶中心结合，该中心将 3'-氨酰基和 3'-肽基末端对齐，以实现亲核氨基和亲电酯羰基的最佳相互作用。推断内在密码子：反密码子结合可能是在核糖体肽合成的早期阶段使 tRNA 3' 末端接近的主要因素，我们想知道原始氨基酸是否可能已被分配给那些结合相应反密码子环的密码子最紧。通过测量反密码子茎环与短寡核苷酸的结合，我们确定家族盒密码子：反密码子配对通常比分裂盒密码子：反密码子配对更紧密。此外，我们发现两个家族盒反密码子茎环可以同时紧密结合一对连续密码子，而两个分裂盒反密码子茎环则不能。分配给家族框的氨基酸对
• EP0407527A4
  申请人：——

  公开号：EP0407527A4

  公开（公告）日：1991-10-30
• CARBOXYL TERMINAL PEPTIDE AND PROTEIN SEQUENCING
  申请人：MILLER, Chad G.

  公开号：EP0407527A1

  公开（公告）日：1991-01-16
• US4935494A
  申请人：——

  公开号：US4935494A

  公开（公告）日：1990-06-19
• US5066785A
  申请人：——

  公开号：US5066785A

  公开（公告）日：1991-11-19