10-(4-hydroxy-3-methoxybenzoyl)oxydecyl-4-hydroxy-3-methoxybenzoate | 84375-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 10-(4-hydroxy-3-methoxybenzoyl)oxydecyl-4-hydroxy-3-methoxybenzoate
• 英文别名: 1,10-decamethylene divanillate；10-(4-Hydroxy-3-methoxybenzoyl)oxydecyl 4-hydroxy-3-methoxybenzoate
• CAS: 84375-76-8
• 化学式: C₂₆H₃₄O₈
• 分子量: 474.551
• InChiKey: SAFCXUZYFBMWGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,10-癸二醇 、 香草酸 以 四氢呋喃 、 对甲苯磺酸 、 甲苯 为溶剂， 生成 10-(4-hydroxy-3-methoxybenzoyl)oxydecyl-4-hydroxy-3-methoxybenzoate
  参考文献：
  名称：

  Cementitious dental compositions which do not inhibit polymerization

  摘要：

  适用于牙科粘接剂、镇静和绝缘基、临时和长期修复剂、根管封闭剂、髓膜覆盖材料、组织包、印模膏和牙科复合材料和硬组织的粘合剂的胶凝性牙科组合物，包括固相和液相。固相包括锡的氧化物或氢氧化物或第二组金属的氧化物或氢氧化物。液相包括螯合化合物，螯合化合物是一种香草酸基团的酯，其中酯是醇、多元醇或聚醚和香草酸或其异构体或同系物之一反应的产物。该组合物还可以含有第二种螯合化合物、Al.sub.2O.sub.3、氢化松香、聚合材料和聚合单体材料。

  公开号：

  US04362510A1

文献信息

• Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli
  作者：Delphine Lamoral-Theys、Laurent Pottier、Frédéric Kerff、François Dufrasne、Fabien Proutière、Nathalie Wauthoz、Philippe Neven、Laurent Ingrassia、Pierre Van Antwerpen、Florence Lefranc

  DOI：10.1016/j.bmc.2010.04.047

  日期：2010.6.1

  A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations <10% of their IC50 growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies. (C) 2010 Elsevier Ltd. All rights reserved.
• STANSBURY, J. W.;BRAUER, G. M., J. BIOMED. MATER. RES., 1985, 19, N 6, 715-725
  作者：STANSBURY, J. W.、BRAUER, G. M.

  DOI：——

  日期：——
• Cementitious dental compositions which do not inhibit polymerization
  申请人：The United States of America as represented by the Secretary of the

  公开号：US04362510A1

  公开（公告）日：1982-12-07

  Cementitious dental compositions suitable for use as luting agents, sedative and insulating bases, temporary and long term restoratives, endodontic sealants, pulp capping materials, tissue packs, impression pastes and adhesives for dental composites and hard tissues comprising a solid phase which includes a metal oxide or hydroxide of tin or a Group II metal and a liquid phase which includes a chelating compound, the chelating compound being an ester of a vanillic acid moiety in which the ester is the product of a reaction of one of an alcohol, a polyhydric alcohol or a polyalkylene glycol and at least one of either vanillic acid or its isomers or homoloynes. The compositions may additionally contain a second chelating compound, Al.sub.2 O.sub.3, an hydrogenated rosin, polymeric materials and polymerizable monomeric materials.

  适用于牙科粘接剂、镇静和绝缘基、临时和长期修复剂、根管封闭剂、髓膜覆盖材料、组织包、印模膏和牙科复合材料和硬组织的粘合剂的胶凝性牙科组合物，包括固相和液相。固相包括锡的氧化物或氢氧化物或第二组金属的氧化物或氢氧化物。液相包括螯合化合物，螯合化合物是一种香草酸基团的酯，其中酯是醇、多元醇或聚醚和香草酸或其异构体或同系物之一反应的产物。该组合物还可以含有第二种螯合化合物、Al.sub.2O.sub.3、氢化松香、聚合材料和聚合单体材料。