3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;oxalate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;oxalate
• 化学式: C29H36N2O9-2
• 分子量: 556.6
• InChiKey: BOHZBFAHOBOJOS-ZMBIFBSDSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  伊伐布雷定 、 草酸 以 二氯甲烷 、 乙醇 为溶剂， 反应 6.0h， 以yielding 340 mg (89%, 0.609 mmol) of ivabradine oxalate的产率得到3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;oxalate
  参考文献：
  名称：

  SALT OF IVABRADINE WITH ADIPIC ACID

  摘要：

  本发明涉及一种含有延迟释放的药物组合物，其包含ivabradine adipate作为活性物质。本发明还涉及制备该组合物和ivabradine的某些盐的过程。

  公开号：

  US20140357860A1

文献信息

• PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF
  申请人：Singh Satyendra Pal

  公开号：US20100179316A1

  公开（公告）日：2010-07-15

  The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and process for its preparation using suitable acid addition salts of ivabradine.

  本发明涵盖了一种通过用酒精氢氯酸处理伊伐布雷定来制备高纯度伊伐布雷定盐酸盐的方法。该发明还涵盖了非晶态伊伐布雷定盐酸盐及其制备方法，使用适当的酸加盐伊伐布雷定。
• Process for the preparation of ivabradine hydrochloride and polymorph thereof
  申请人：Ind-Swift Laboratories Limited

  公开号：US08212026B2

  公开（公告）日：2012-07-03

  The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and process for its preparation using suitable acid addition salts of ivabradine.

  本发明涵盖了一种通过用酒精氢氯酸处理伊伐布雷定来制备高纯度伊伐布雷定盐酸盐的方法。该发明进一步涵盖了非晶态伊伐布雷定盐酸盐及其制备方法，使用适当的酸加盐伊伐布雷定。
• IVABRADINE-CONTAINING PHARMACEUTICAL COMPOSITION WITH MODIFIED RELEASE
  申请人：Gidwani Ramesh Matioram

  公开号：US20130116239A1

  公开（公告）日：2013-05-09

  The present invention relates to pharmaceutical compositions with delayed release which contain ivabradine adipate as active substance. The present invention furthermore relates to processes for the preparation of this composition and certain salts of ivabradine.

  本发明涉及含有延迟释放的药物组合物，其包含作为活性物质的阿维拉布丁脂酸盐。本发明还涉及制备该组合物和阿维拉布丁的某些盐的过程。
• SALT OF IVABRADINE WITH ADIPIC ACID
  申请人：ratiopharm GmbH

  公开号：US20140357860A1

  公开（公告）日：2014-12-04

  The present invention relates to pharmaceutical compositions with delayed release which contain ivabradine adipate as active substance. The present invention furthermore relates to processes for the preparation of this composition and certain salts of ivabradine.

  本发明涉及一种含有延迟释放的药物组合物，其包含ivabradine adipate作为活性物质。本发明还涉及制备该组合物和ivabradine的某些盐的过程。