N-[1-({2-chloro-5-[(cyclopropylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide | 1253186-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[1-({2-chloro-5-[(cyclopropylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide
• 英文别名: N-[1-[[2-chloro-5-(cyclopropylmethoxy)phenyl]methyl]pyrazol-3-yl]-2,6-difluorobenzamide
• CAS: 1253186-27-4
• 化学式: C₂₁H₁₈ClF₂N₃O₂
• 分子量: 417.843
• InChiKey: JMKTXWGIYGUDLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-{1-[(2-chloro-5-hydroxyphenyl)methyl]-1H-pyrazol-3-yl}-2,6-difluorobenzamide 、 溴甲基环丙烷 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.17h， 生成 N-[1-({2-chloro-5-[(cyclopropylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide
  参考文献：
  名称：

  [EN] N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS
  [FR] CARBOXAMIDES N-PYRAZOLYL EN TANT QU'INHIBITEURS DU CANAL CRAC

  摘要：

  本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物，以及它们在治疗过敏性疾病、炎症性疾病和免疫系统疾病等疾病、状况或障碍中的应用。

  公开号：

  WO2010122089A1

文献信息

• N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS
  申请人：Allen David George

  公开号：US20120053150A1

  公开（公告）日：2012-03-01

  The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

  本发明涉及酰胺化合物、其制备方法、含有这些化合物的药物组合物以及它们在治疗过敏性疾病、炎症性疾病和免疫系统疾病等疾病、症状或障碍中的应用。
• COMPOUNDS
  申请人：Gore Paul Martin

  公开号：US20100273744A1

  公开（公告）日：2010-10-28

  The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

  本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物以及它们在治疗过敏性疾病、炎症性疾病和免疫系统疾病等疾病、症状或障碍中的应用。
• N-pyrazolyl carboxamides as CRAC channel inhibitors
  申请人：Allen David George

  公开号：US08399436B2

  公开（公告）日：2013-03-19

  The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

  本发明涉及酰胺化合物、其制备方法、含有这些化合物的药物组合物以及它们在治疗过敏性疾病、炎症性疾病和免疫系统疾病等疾病、状况或紊乱中的应用。
• NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20170114060A1

  公开（公告）日：2017-04-27

  The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a Filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
• US8399436B2
  申请人：——

  公开号：US8399436B2

  公开（公告）日：2013-03-19