1-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime | 1267687-86-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime
• 英文别名: 1-(4-Bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime；N-[1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethylidene]hydroxylamine
• CAS: 1267687-86-4
• 化学式: C₈H₄BrF₄NO
• 分子量: 286.023
• InChiKey: YABCADIXIDZPNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以66%的产率得到6-bromo-3-trifluoromethyl-benzo[d]isoxazole
  参考文献：
  名称：

  [EN] ARYL-HYDROXYETHYLAMINO-PYRIMIDINES AND TRIAZINES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE
  [FR] ARYL-HYDROXYÉTHYLAMINO-PYRIMIDINES ET TRIAZINES EN TANT QUE MODULATEURS D'AMIDE D'ACIDE GRAS HYDROLASE

  摘要：

  描述了某些芳基-羟乙基氨基嘧啶和三嗪化合物，这些化合物可用作FAAH抑制剂。这些化合物可用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、紊乱和症状，如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢障碍和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。

  公开号：

  WO2009105220A1
• 作为产物：
  描述：

  1-(4-溴-2-氟苯基)-2,2,2-三氟乙酮 、 盐酸羟胺 、 sodium acetate 在 乙酸乙酯 、 水 、 Sodium sulfate-III 作用下， 以 甲醇 为溶剂， 反应 43.0h， 以The title compound was obtained as a 70:30 ratio of the E and Z oxime的产率得到1-(4-bromo-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone oxime
  参考文献：
  名称：

  Ethylene diamine modulators of fatty acid hydrolase

  摘要：

  本文介绍了公式（I）中的某些乙二胺化合物，这些化合物可用作FAAH抑制剂。这些化合物可用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、紊乱和条件，例如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢紊乱和运动障碍（例如多发性硬化症）的方法。还公开了合成这些化合物的方法。

  公开号：

  US08906914B2

文献信息

• [EN] ETHYLENE DIAMINE MODULATORS OF FATTY ACID AMIDE HYDROLASE<br/>[FR] MODULATEURS D'ÉTHYLÈNE DIAMINE D'UNE AMIDE HYDROLASE D'ACIDE GRAS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011022348A1

  公开（公告）日：2011-02-24

  Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  描述了Formula (I)中的某些乙烯二胺化合物，这些化合物可作为FAAH抑制剂。这种化合物可用于制备药物组合物，并用于治疗由脂肪酸酰胺水解酶(FAAH)活性介导的疾病状态、紊乱和情况，如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢紊乱和运动障碍(例如多发性硬化)。还公开了合成这种化合物的方法。
• Aryl - Hydroxyethylamino - Pyrimidines and Triazines as Modulators of Fatty Acid amide Hydrolase
  申请人：Apodaca Richard

  公开号：US20090264429A1

  公开（公告）日：2009-10-22

  Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  描述了某些芳基-羟乙基氨基嘧啶和三嗪化合物，这些化合物可用作FAAH抑制剂。这些化合物可以用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、障碍和病况的方法，例如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢障碍和运动障碍（例如多发性硬化症）。还公开了合成这些化合物的方法。
• ETHYLENE DIAMINE MODULATORS OF FATTY ACID HYDROLASE
  申请人：Hawryluk Natalie A.

  公开号：US20120149696A1

  公开（公告）日：2012-06-14

  Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  本文描述了公式（I）的某些乙烯二胺化合物，它们可用作FAAH抑制剂。这些化合物可用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、疾病和情况，如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢障碍和运动障碍（例如多发性硬化症）的方法。还公开了合成这些化合物的方法。
• Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase
  申请人：Apodaca Richard

  公开号：US08598202B2

  公开（公告）日：2013-12-03

  Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  本文介绍了某些芳基-羟乙基氨基嘧啶和三嗪化合物，它们可用作FAAH（脂肪酸酰胺水解酶）抑制剂。这些化合物可用于制备药物组合物和治疗由FAAH活性介导的疾病状态、疾病和情况，例如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢障碍和运动障碍（如多发性硬化症）。本文还揭示了合成这些化合物的方法。
• [EN] ARYL-HYDROXYETHYLAMINO-PYRIMIDINES AND TRIAZINES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE<br/>[FR] ARYL-HYDROXYÉTHYLAMINO-PYRIMIDINES ET TRIAZINES EN TANT QUE MODULATEURS D'AMIDE D'ACIDE GRAS HYDROLASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009105220A1

  公开（公告）日：2009-08-27

  Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.

  描述了某些芳基-羟乙基氨基嘧啶和三嗪化合物，这些化合物可用作FAAH抑制剂。这些化合物可用于制备药物组合物和治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态、紊乱和症状，如焦虑、疼痛、炎症、睡眠障碍、进食障碍、能量代谢障碍和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。