4-(p-vinylphenylmethyloxy)phenol | 59498-44-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(p-vinylphenylmethyloxy)phenol
• 英文别名: 4-(4-vinylbenzyloxy)phenol；4-[(4-Ethenylphenyl)methoxy]phenol
• CAS: 59498-44-1
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: BCKCXTNVBSRBFS-UHFFFAOYSA-N

物化性质

• 熔点：
  143-144 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• 沸点：
  396.7±22.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(p-vinylphenylmethyloxy)phenol 在 氢氧化钾 、 四溴化碳 、 四丁基溴化铵 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 60.0h， 生成 3,5-bis(p-vinylphenylmethyloxy-p-phenyloxyethyleneoxyethyleneoxy)benzyl alcohol
  参考文献：
  名称：

  Polymer immobilization of bis(oxazoline) ligands using dendrimers as cross-linkers

  摘要：

  Homopolymers of bis(oxazoline) ligands can be used to prepare efficient catalysts for cyclopropanation reactions. However, the low accessibility to most bis(oxazoline) moieties leads to a low copper loading. As a consequence, the transmission of chiral information from the complexed polymer is not very efficient and only a few chiral cyclopropane molecules are obtained from each molecule of chiral ligand. The use of suitable dendrimers as cross-linkers in the polymerization process allows better copper functionalization. As a consequence the productivity of chiral cyclopropanes per molecule of chiral ligand greatly increases, which improves the ligand economy and the chirality transfer. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00074-0
• 作为产物：
  描述：

  4-氯甲基苯乙烯 、 对苯二酚 在 甲基三辛基氯化铵 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以44%的产率得到4-(p-vinylphenylmethyloxy)phenol
  参考文献：
  名称：

  A Flexible and Versatile Strategy for the Covalent Immobilization of Chiral Catalysts Based on Pyridinebis(oxazoline) Ligands

  摘要：

  Flexible and versatile methods have been developed for the immobilization of chiral pyridinebis(oxazoline) ligands by covalent bonding to a solid support, either by grafting or by polymerization. Different spacers can easily be introduced to modulate the support-ligand distance and the electronic properties of the chiral ligand. As an example, 2,6-bis [(S)-4-isopropyloxazolin-2-yl] pyridine has been immobilized on polystyrene resins, both on a Merrifield-type resin by grafting and on supports prepared by polymerization of 4-vinyl-substituted ligands. The corresponding Ru complexes have been tested as catalysts in the cyclopropanation reaction between styrene and ethyl diazoacetate. The catalytic activity, the enantioselectivity, and the recyclability are strongly dependent on the catalyst preparation method and the total exclusion of oxygen and moisture in the filtration process. Under such optimized conditions, yields over 60% with up to 90% ee can be obtained in four successive reactions-the best cyclopropanation results described to date for a chiral solid ruthenium catalyst.

  DOI：

  10.1021/jo050504l

文献信息

• Catalysts Based on Metal Complexes for the Synthesis of Optically Active Chrysanthemic Acid
  申请人：Carloni Silvia

  公开号：US20080021237A1

  公开（公告）日：2008-01-24

  Catalysts are described based on metal complexes derived from optically active S compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.

  催化剂是基于光学活性S化合物衍生的金属配合物描述的，这些化合物来自于双噁唑和水杨醛亚胺类，支持在有机或无机基质上，并特别用于合成光学活性菊酸。
• Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid
  申请人：Carloni Silvia

  公开号：US20100204038A1

  公开（公告）日：2010-08-12

  Catalysts are described based on metal complexes derived from optically active s compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.

  催化剂是基于由光学活性s化合物衍生的金属配合物描述的，这些化合物选自包括支持在有机或无机基质上的双噁唑啉和水杨醛亚胺的类别，并特别用于合成光学活性菊酸。
• Synthesis of periphery-functionalized dendritic polyethers
  作者：Enrique Dı́ez-Barra、Raquel González、Prado Sánchez-Verdú、Juan Tolosa

  DOI：10.1016/j.tet.2003.12.003

  日期：2004.2

  New dendritic polyethers with bromo-, hydroxy- and vinyl-end groups have been synthesized by a convergent strategy. Planar, 1,3,5-trischlorocarbonylbenzene and 1,3,5-trihydroxybenzene, and tetrahedral, tetrakis(p-hydroxyphenyl)methane, cores have been used. (C) 2003 Elsevier Ltd. All rights reserved.
• CATALYSTS BASED ON COPPER COMPLEXES FOR THE SYNTHESIS OF OPTICALLY ACTIVE CHRYSANTHEMIC ACID
  申请人：ENDURA S.p.A.

  公开号：EP1765496B1

  公开（公告）日：2010-07-14
• CATALYSTS BASED ON METAL COMPLEXES FOR THE SYNTHESIS OF OPTICALLY ACTIVE CHRYSANTHEMIC ACID
  申请人：ENDURA S.p.A.

  公开号：EP1765496A1

  公开（公告）日：2007-03-28