Benzoesaeuremethylester-2-p-methoxyphenylsulfonat | 35034-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoesaeuremethylester-2-p-methoxyphenylsulfonat
• 英文别名: methyl 2-(4-methoxyphenyl)sulfonyloxybenzoate
• CAS: 35034-45-8
• 化学式: C₁₅H₁₄O₆S
• 分子量: 322.339
• InChiKey: WOYADWGUHAEYGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.25
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  Benzoesaeuremethylester-2-p-methoxyphenylsulfonat 在 lithium hydroxide 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 4-Methoxy-benzenesulfonic acid 2-o-tolylcarbamoyl-phenyl ester
  参考文献：
  名称：

  Novel sulfonate Derivatives: potent antimitotic agents

  摘要：

  The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported, Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+)cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00279-7
• 作为产物：
  描述：

  对甲氧基苯磺酰氯 、 水杨酸甲酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到Benzoesaeuremethylester-2-p-methoxyphenylsulfonat
  参考文献：
  名称：

  Novel sulfonate Derivatives: potent antimitotic agents

  摘要：

  The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported, Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+)cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00279-7

文献信息

• Novel sulfonate Derivatives: potent antimitotic agents
  作者：Stephen L. Gwaltney、Hovis M. Imade、Qun Li、Laura Gehrke、R.Bruce Credo、Robert B. Warner、Jang Yun Lee、Peter Kovar、David Frost、Shi-Chung Ng、Hing L. Sham

  DOI：10.1016/s0960-894x(01)00279-7

  日期：2001.7

  The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported, Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+)cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.