5-benzyloxy-1,4dihydro-6-methyl-4-oxopyridine-3-carbaldehyde | 1219537-32-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-benzyloxy-1,4dihydro-6-methyl-4-oxopyridine-3-carbaldehyde
• 英文别名: 6-methyl-4-oxo-5-phenylmethoxy-1H-pyridine-3-carbaldehyde
• CAS: 1219537-32-2
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: WICDDPZTSMJDHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-benzyloxy-5-(dimethylaminomethyl)-2-methyl-4(1H)-pyridinone 在 N-羟基丁二酰亚胺 、 cobalt(II) diacetate tetrahydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 以1.44 g的产率得到5-benzyloxy-1,4dihydro-6-methyl-4-oxopyridine-3-carbaldehyde
  参考文献：
  名称：

  Synthesis of 5-benzyloxy-1,4-dihydro-6-methyl-4-oxopyridine-3-carbaldehyde by aerobic oxidation of the 5-dimethylaminomethyl analogue: optimisation of the reaction conditions

  摘要：

  A successful introduction of the formyl group at position 5 of 3-hydroxypyridin-4-one was achieved by aerobic oxidation, catalysed by NHS/Co(II). To obtain a practical yield, the reaction conditions were optimised. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.027

文献信息

• Synthesis of 5-benzyloxy-1,4-dihydro-6-methyl-4-oxopyridine-3-carbaldehyde by aerobic oxidation of the 5-dimethylaminomethyl analogue: optimisation of the reaction conditions
  作者：Yong Min Ma、Robert C Hider

  DOI：10.1016/j.tetlet.2010.01.027

  日期：2010.3

  A successful introduction of the formyl group at position 5 of 3-hydroxypyridin-4-one was achieved by aerobic oxidation, catalysed by NHS/Co(II). To obtain a practical yield, the reaction conditions were optimised. (C) 2010 Elsevier Ltd. All rights reserved.