methyl 3-propoxypropanoate | 14144-39-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-propoxypropanoate
• 英文别名: methyl 3-propoxypropionate；3-propoxy-propionic acid methyl ester；3-Propyloxy-propionsaeure-methylester；O-Propyl-hydracrylsaeure-methylester；3-Propoxy-propionsaeure-methylester；β-Propoxy-propionsaeure-methylester
• CAS: 14144-39-9
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: DMHHINXESLPPMV-UHFFFAOYSA-N

物化性质

• 沸点：
  205.8°C (rough estimate)
• 密度：
  1.0429 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 3-propoxypropanoate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 1.0h， 以73%的产率得到丙氧基丙醇
  参考文献：
  名称：

  Vodovozova, E. L.; Mikhalev, I. I.; Rzhaninova, A. A., Russian Journal of Bioorganic Chemistry, 1995, vol. 21, # 9, p. 626 - 632

  摘要：

  DOI：
• 作为产物：
  描述：

  丙醇 、 3-溴丙酸甲酯 在 sodium 作用下， 反应 12.0h， 以59%的产率得到methyl 3-propoxypropanoate
  参考文献：
  名称：

  Vodovozova, E. L.; Mikhalev, I. I.; Rzhaninova, A. A., Russian Journal of Bioorganic Chemistry, 1995, vol. 21, # 9, p. 626 - 632

  摘要：

  DOI：

文献信息

• Catalytic Olefin Hydroalkoxylation by Nano Particles of Pollucite
  作者：Sara Zamanian、Ali Nemati Kharat

  DOI：10.1071/ch14492

  日期：——

  The catalytic hydroalkoxylation of α,β-unsaturated esters, nitriles, and ethers with aliphatic and aromatic alcohols over pollucite using thermal and microwave-assisted methods was investigated. To study the effect of the alcohol structures on the mechanism of the hydroalkoxylation reaction, different alcohols, such as methanol to butanol, cyclohexanol, phenol, and 2-ethylhexanol were used. The activities of pollucite, in contrast to other basic solids, were scarcely affected by the presence of air and moisture. The correlation between alcohol acidity and reaction activity is discussed. The prepared pollucite was characterized by X‐ray diffraction, volumetric nitrogen adsorption surface area analysis, and CO2 temperature‐programmed desorption. Scanning electron microscopy analysis revealed that the size of the modified nano catalyst particles was under 40 nm.

  本研究采用热和微波辅助方法，研究了α,β-不饱和酯类、腈类和醚类与脂肪族和芳香族醇在沸石上的催化加氢烷氧基化反应。为了研究醇结构对羟基烷氧基化反应机理的影响，使用了不同的醇，如甲醇、丁醇、环己醇、苯酚和 2-乙基己醇。与其他碱性固体相比，波来石的活性几乎不受空气和水分的影响。本文讨论了醇酸度与反应活性之间的相关性。通过 X 射线衍射、体积氮吸附表面积分析和 CO2 温度编程解吸法对制备的波来石进行了表征。扫描电子显微镜分析表明，改性纳米催化剂颗粒的尺寸小于 40 纳米。
• SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS
  申请人：Bignan Gilles

  公开号：US20110294780A1

  公开（公告）日：2011-12-01

  The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

  本发明涉及式(I)的化合物，制备这些化合物的方法，组合物，中间体及其衍生物，并用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿关节炎，感染性关节炎，儿童关节炎，银屑病性关节炎，反应性关节炎），与骨相关的疾病（包括与骨形成有关的疾病），乳腺癌（包括对抗雌激素治疗无效的癌症），心血管疾病，软骨相关疾病（如软骨损伤/丧失，软骨退化以及与软骨形成有关的疾病），软骨发育不良，软骨肉瘤，慢性腰部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺疾病，糖尿病，能量稳态紊乱，痛风，假性痛风，脂质紊乱，代谢综合征，多发性骨髓瘤，肥胖，骨关节炎，遗传性骨发育不全，骨溶解性骨转移，软骨软化症，骨质疏松症，帕金森病，牙周病，多肌痛风，Reiter综合征，重复性应激损伤，高血糖，血糖水平升高和胰岛素抵抗等病症的方法。
• NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
  申请人：BOUCHARD Hervé

  公开号：US20120225089A1

  公开（公告）日：2012-09-06

  Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided.

  本发明提供了隐藻素偶联物及其包含它们的组合物。还提供了制备和使用此类化合物的方法。
• Photoactive compounds
  申请人：Rahman Dalil M.

  公开号：US20070111138A1

  公开（公告）日：2007-05-17

  The present invention relates to novel photoacid generators.

  本发明涉及新型光酸发生剂。
• Photoactive Compounds
  申请人：Padmanaban Munirathna

  公开号：US20080131811A1

  公开（公告）日：2008-06-05

  The present application relates to a compound of formula AiXi where Ai is an organic onium cation; and Xi is an anion of the formula X—CF 2 CF 2 OCF 2 CF 2 —SO 3 − . The compounds are useful as photoactive materials.

  本申请涉及到一个化合物的配方AiXi，其中Ai是有机的离子阳离子；Xi是公式X-CF2CF2OCF2CF2-SO3-的阴离子。这些化合物可用作光活性材料。