2-methoxyethoxyphenyl phenyl methane | 732250-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methoxyethoxyphenyl phenyl methane
• 英文别名: 1-Benzyl-2-(2-methoxyethoxy)benzene
• CAS: 732250-24-7
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: CEZLVONCXYYMPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methoxyethoxyphenyl phenyl methane 在 aluminium(III) iodide 、 仲丁基锂 、 鹰爪豆碱 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 12.0h， 生成 (1-苯基乙基)-苯酚
  参考文献：
  名称：

  Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent

  摘要：

  Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and up to 94% cc. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable cc. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.058
• 作为产物：
  描述：

  苯甲基苯酚 、 2-溴乙基甲基醚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 2-methoxyethoxyphenyl phenyl methane
  参考文献：
  名称：

  ORGANIC COMPOUNDS

  摘要：

  该发明涉及3,5-取代哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖肾素活性的疾病（=紊乱）；该类化合物用于制备用于治疗依赖肾素活性疾病的药物配方；该类化合物用于治疗依赖肾素活性的疾病；包括3,5-取代哌啶化合物的药物配方，和/或包括给予3,5-取代哌啶化合物的治疗方法，一种用于制造3,5-取代哌啶化合物的方法，以及其合成的新中间体和部分步骤。优选的化合物（也可以存在为盐）具有式I的结构，其中R1、R2、T、R3和R4如规范中定义。

  公开号：

  US20090233920A1

文献信息

• Asymmetric alkylation of diarylmethane derivatives
  作者：James A. Wilkinson、Steven B. Rossington、Sylvie Ducki、John Leonard、Nigel Hussain

  DOI：10.1016/j.tet.2005.11.044

  日期：2006.2

  Deprotonation-alkylation of prochiral diarylinethane substrates using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and Lip to 94% ee. A variety of enantioselective alkylations, silylations and stannylations have been performed on four different diarylmethanes. Surrogates for (+)-sparteine have also been applied in this Study including a novel surrogate. (c) 2005 Elsevier Ltd. All rights reserved.
• ORGANIC COMPOUNDS
  申请人：Breitenstein Werner

  公开号：US20090233920A1

  公开（公告）日：2009-09-17

  The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

  该发明涉及3,5-取代哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖肾素活性的疾病（=紊乱）；该类化合物用于制备用于治疗依赖肾素活性疾病的药物配方；该类化合物用于治疗依赖肾素活性的疾病；包括3,5-取代哌啶化合物的药物配方，和/或包括给予3,5-取代哌啶化合物的治疗方法，一种用于制造3,5-取代哌啶化合物的方法，以及其合成的新中间体和部分步骤。优选的化合物（也可以存在为盐）具有式I的结构，其中R1、R2、T、R3和R4如规范中定义。
• Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent
  作者：James A Wilkinson、Steven B Rossington、John Leonard、Nigel Hussain

  DOI：10.1016/j.tetlet.2004.05.058

  日期：2004.7

  Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (-)-sparteine has been carried Out in excellent yields and up to 94% cc. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable cc. (C) 2004 Elsevier Ltd. All rights reserved.