[2-(Hydroxymethyl)-1,3-dithiolan-2-yl]methanol | 85598-26-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: [2-(Hydroxymethyl)-1,3-dithiolan-2-yl]methanol
• CAS: 85598-26-1
• 化学式: C₅H₁₀O₂S₂
• 分子量: 166.265
• InChiKey: PVFWSUZNYCKKPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  91.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2-(Hydroxymethyl)-1,3-dithiolan-2-yl]methanol 在 咪唑 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.67h， 生成 2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]dithiolane 1-oxide
  参考文献：
  名称：

  Syntheses and antiviral activities of 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents

  摘要：

  Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00250-3
• 作为产物：
  描述：

  C₁₉H₁₈O₄S₂ 在 氨 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以88%的产率得到[2-(Hydroxymethyl)-1,3-dithiolan-2-yl]methanol
  参考文献：
  名称：

  Syntheses and antiviral activities of 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents

  摘要：

  Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00250-3

文献信息

• Hamor, T. A.; Jones, A. S.; Jones, R. H., Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 33 - 35
  作者：Hamor, T. A.、Jones, A. S.、Jones, R. H.、McGuigan, C.、Walker, R. T.

  DOI：——

  日期：——
• HAMOR, T. A.;JONES, A. S.;JONES, H.;MCGUIGAN, C.;WALKER, R. T., J. HETEROCYCL. CHEM., 1983, 20, N 1, 33-35
  作者：HAMOR, T. A.、JONES, A. S.、JONES, H.、MCGUIGAN, C.、WALKER, R. T.

  DOI：——

  日期：——
• Syntheses and antiviral activities of 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents
  作者：Moon Woo Chun、Dae Hong Shin、Hyung Ryong Moon、Jeewoo Lee、Hokoon Park、Lak Shin Jeong

  DOI：10.1016/s0960-894x(97)00250-3

  日期：1997.6

  Novel 1,3-dioxolanyl-, 1,3-oxathiolanyl- and 1,3-dithiolanylnucleosides with 2-hydroxymethyl substituents (1a-4b) were each synthesized with good yields through the condensation of dinucleophiles (oxygen and/or sulfur) with 1,3-dibenzoxy-2-propanone methyl ketal as a key step. (C) 1997 Elsevier Science Ltd.