4-Ethylbenzolsulfanilid | 64329-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Ethylbenzolsulfanilid
• 英文别名: 4-ethyl-N-phenylbenzenesulfonamide
• CAS: 64329-90-4
• 化学式: C₁₄H₁₅NO₂S
• mdl: MFCD01136686
• 分子量: 261.345
• InChiKey: VCSDJJRLCXPKJM-UHFFFAOYSA-N

物化性质

• 熔点：
  55 °C(Solv: ethanol (64-17-5))
• 沸点：
  401.1±38.0 °C(Predicted)
• 密度：
  1.236±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙基苯磺酰胺 、 环己酮 在 1,10-菲罗啉 、 palladium(II) trifluoroacetate 、 氧气 作用下， 以 甲苯 为溶剂， 反应 40.0h， 以79%的产率得到4-Ethylbenzolsulfanilid
  参考文献：
  名称：

  Palladium-catalyzed arylation of aryl sulfonamides with cyclohexanones

  摘要：

  Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of aryl sulfonamides with cyclohexanones. Various N-aryl sulfonamides were selectively obtained in good yields using molecular oxygen as oxidant. The reaction tolerated a wide range of functionalities. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2013.11.023

文献信息

• Palladium-catalyzed <i>N</i>-arylsulfonamide formation from arylsulfonyl hydrazides and nitroarenes
  作者：Feng Zhao、Bin Li、Huawen Huang、Guo-Jun Deng

  DOI：10.1039/c5ra26588f

  日期：——

  A palladium-catalyzed construction for N-arylsulfonamide from nitroarenes and arylsulfonyl hydrazides is developed. In this protocol, abundant and stable nitroarenes serve as the nitrogen sources by in situ reduction reaction of hydrogen released from arylsulfonyl hydrazides. No external oxidants or reductants are needed for this kind of transformation.

  开发了钯催化的硝基芳烃和芳基磺酰肼的N-芳基磺酰胺的结构。在该方案中，丰富而稳定的硝基芳烃通过原位还原从芳基磺酰肼释放的氢而作为氮源。这种转化不需要外部氧化剂或还原剂。
• 6-Aminoisoquinoline Compounds
  申请人：deLong Mitchell A.

  公开号：US20080167340A1

  公开（公告）日：2008-07-10

  6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

  提供了影响、抑制或减少激酶作用的6-氨基异喹啉化合物。还提供了包括治疗有效量的6-氨基异喹啉化合物和药用可接受载体的药物组合物。还提供了使用这些化合物和/或组合物来影响疾病状态或疾病条件，如癌症、肥胖和青光眼的各种方法。
• 6-AMINOISOQUINOLINE COMPOUNDS
  申请人：deLong Mitchell A.

  公开号：US20110183965A1

  公开（公告）日：2011-07-28

  6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

  本发明提供了影响、抑制或减少激酶作用的6-氨基异喹啉化合物。还提供了包括治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的制药组合物。还提供了使用这些化合物和/或组合物影响疾病状态或病症，如癌症、肥胖和青光眼的各种方法。
• US8034943B2
  申请人：——

  公开号：US8034943B2

  公开（公告）日：2011-10-11
• US8357699B2
  申请人：——

  公开号：US8357699B2

  公开（公告）日：2013-01-22