8-Pahsa | 2095569-12-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Pahsa
• 英文别名: 8-hexadecanoyloxyoctadecanoic acid
• CAS: 2095569-12-1
• 化学式: C₃₄H₆₆O₄
• 分子量: 538.9
• InChiKey: PXZVHHRFDCMNSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.2
• 重原子数：
  38
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Fatty acid esters of hydroxy fatty acids (FAHFAs) for use in the treatment of type 1 diabetes
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US11013711B2

  公开（公告）日：2021-05-25

  Provided herein are methods for treating type 1 diabetes and its sequelae (e.g., cardiovascular, renal or neurologic diseases for which type 1 diabetes is a risk factor) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a fatty acid ester of a hydroxy fatty acid (FAHFA), or a pharmaceutically acceptable salt thereof.

  本文提供了用于治疗有需要的受试者的1型糖尿病及其后遗症（例如1型糖尿病是其危险因素的心血管、肾脏或神经系统疾病）的方法，包括向受试者施用治疗有效量的羟基脂肪酸酯（FAHFA）或其药学上可接受的盐。
• Fatty Acid Esters Of Hydroxy Fatty Acids (FAHFAs) For Use In The Treatment Of Type 1 Diabetes
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20190151276A1

  公开（公告）日：2019-05-23

  Provided herein are methods for treating type 1 diabetes and its sequelae (e.g., cardiovascular, renal or neurologic diseases for which type 1 diabetes is a risk factor) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a fatty acid ester of a hydroxy fatty acid (FAHFA), or a pharmaceutically acceptable salt thereof.
• [EN] METHODS OF PREVENTING AND TREATING INFLAMMATORY BOWEL DISEASE WITH BRANCHED FATTY ACID ESTERS OF HYDROXY FATTY ACIDS (FAHFAS)<br/>[FR] PROCÉDÉS DE PRÉVENTION ET DE TRAITEMENT DE MALADIES INTESTINALES INFLAMMATOIRES AVEC DES ESTERS D'ACIDES GRAS RAMIFIÉS D'ACIDES GRAS HYDROXYLÉS (FAHFA)
  申请人：BETH ISRAEL DEACONESS MEDICAL CT INC

  公开号：WO2017070515A2

  公开（公告）日：2017-04-27

  The invention provides a method and pharmaceutical composition useful in preventing and treating colitis with branched fatty acid esters of hydroxy fatty acids (FAHFAs). For example, the invention is related to the use of branched palmitic acid esters of hydroxy stearic acids (PAHS As), with beneficial metabolic and anti -inflammatory effects. The composition contains effective amounts of PAHS As and a pharmaceutically acceptable vehicle, carrier and/or diluent. The pharmaceutical compositions are prepared for oral administration in single or combination therapies.
• [EN] FATTY ACID ESTERS OF HYDROXY FATTY ACIDS (FAHFAS) FOR USE IN THE TREATMENT OF TYPE 1 DIABETES<br/>[FR] ESTERS D'ACIDES GRAS D'ACIDES GRAS HYDROXYLÉS (FAHFAS) POUR UNE UTILISATION DANS LE TRAITEMENT DU DIABÈTE DE TYPE 1
  申请人：BETH ISRAEL DEACONESS MEDICAL CT INC

  公开号：WO2017214527A1

  公开（公告）日：2017-12-14

  Provided herein are methods for treating type 1 diabetes and its sequelae (e.g., cardiovascular, renal or neurologic diseases for which type 1 diabetes is a risk factor) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a fatty acid ester of a hydroxy fatty acid (FAHFA), or a pharmaceutically acceptable salt thereof.