bis-(2,6-diisopropylphenyl)chlorophosphite | 174300-30-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(2,6-diisopropylphenyl)chlorophosphite
• 英文别名: Chloro-bis[2,6-di(propan-2-yl)phenoxy]phosphane
• CAS: 174300-30-2
• 化学式: C₂₄H₃₄ClO₂P
• 分子量: 420.96
• InChiKey: XZLFHUPFYYPNHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S,3S)-2-[(ferrocenylidene)-amino]-3-methyl-pentan-1-ol 、 bis-(2,6-diisopropylphenyl)chlorophosphite 在 三乙胺 作用下， 以 苯 为溶剂， 以86%的产率得到(2S,3S)-bis-(2,6-diisopropylphenyl)-2-[(ferrocenylidene)-amino]-3-methyl-pentylphosphite
  参考文献：
  名称：

  Iminoarylphosphites with ferrocenylidene and cymantrenylidene fragments: Coordination properties and use in palladium-catalysed asymmetric allylic substitution

  摘要：

  Complexation of the chiral P,N-bidentate ferrocene- and cymantrene-based iminoarylphosphites with [Rh(CO)(2)O-12, [Rh(COD)(THF)(2)]BF4, [Pd(allyl)Cl](2), [Pt(allyl)Cl](4), [Pd(COD)Cl-2] and [Pt(COD)Cl-2] was found to give chelate complexes [Rh(CO)(eta(2)-PN)Cl], [Rh(COD)(eta(2)-PN)]BF4, [M(allyl)(eta(2)-PN)]BF4 (M = Pd, Pt) and cis-[M(eta(2)-PN)Cl-2)] (M = Pd, Pt), correspondingly. With the new P,N-ligands, up to 97% ee was achieved in the asymmetric Pd-catalysed alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate. In the enantioselective amination of 1,3-diphenyl-2-propenyl acetate with sodium diformylamide, up to 96% enantioselectivity was achieved. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2006.06.025
• 作为产物：
  描述：

  丙泊酚 在 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 生成 bis-(2,6-diisopropylphenyl)chlorophosphite
  参考文献：
  名称：

  Metathesis for catalyst design: metacatalysis

  摘要：

  Prior studies have shown an effective way to produce diverse ligand sets for catalyst discovery is by using mixtures of monodentate forms to generate catalysts in situ. Research described here was performed to illustrate that alkene-functionalized monodentate ligands could be used in this way and in another that increases the diversity of the ligand library in an interesting way. Specifically, we hypothesized that as well as being used as monomers, these alkenes could be cross metathesized in situ immediately before the catalysis step. This combination of metathesis to form ligands in situ, then catalysis is referred to here as metacatalysis. In the event, a library of quinidine and quinine alkaloid-derived phosphites were tested as mixtures of monomers and dimers formed via metathesis in situ. The data obtained illustrated that metacatalysis can be used to identify ligands that positively and negatively modulate enantioselectivities in iridium-mediated hydrogenations of a,alpha,beta-unsaturated carboxylic acid derivatives, relative to the mixtures of the monomeric forms used. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.040

文献信息

• US5521237A
  申请人：——

  公开号：US5521237A

  公开（公告）日：1996-05-28