N¹,4-dimethyl-N'¹-(1-phenylethylidene)-1-benzenesulfonohydrazide | 63383-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,4-dimethyl-N'¹-(1-phenylethylidene)-1-benzenesulfonohydrazide
• 英文别名: N-methyl-N'-(1'-phenylethylidene)-4-methylbenzenesulfonohydrazide；N,4-dimethyl-N-(1-phenylethylideneamino)benzenesulfonamide
• CAS: 63383-11-9
• 化学式: C₁₆H₁₈N₂O₂S
• 分子量: 302.397
• InChiKey: SHTWWIFIEBJAFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  58.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯乙酮 在 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 36.5h， 生成 N¹,4-dimethyl-N'¹-(1-phenylethylidene)-1-benzenesulfonohydrazide
  参考文献：
  名称：

  N-Alkylation of tosylhydrazones in the presence of triphenylphosphine

  摘要：

  An efficient N-alkylation reaction of tosylhydrazones was developed in the presence of triphenylphosphine; triphenylphosphine played a key role in the transformation. A range of N-alkylated tosylhydrazones were prepared in good to high yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.131

文献信息

• One-Pot Synthesis of <i>N</i>-Alkyl Sulfonyl Hydrazones by Dialkyl Acetylenedicarboxylate-Mediated Reaction of Trialkylphosphites with Sulfonyl Hydrazones
  作者：Seyed Abolghasem Hashemi

  DOI：10.1080/00397911.2013.786088

  日期：2013.12.17

  Stable derivatives of N-alkyl sulfonyl hydrazone were obtained in excellent yields from the reaction between electron-deficient acetylenic ester compounds and sulfonyl hydrazones in the presence of trialkylphosphites in dichloromethan at room temperature. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]